| アブストラクト | BACKGROUND: We examined the association between socio-demographic determinants and uptake of childhood Measles, Mumps & Rubella (MMR) vaccines and the association between pregnant women's pertussis vaccine uptake and their children's MMR vaccine uptake. METHODS: We used nationally-representative linked mother-baby electronic records from the United Kingdom's Clinical-Practice-Research-Datalink. We created a birth cohort of children born between 01.01.2000 and 12.12.2020. We estimated the proportion vaccinated with first MMR vaccine by age 2 years and first and second MMR vaccines by age 5 years. We used survival-analysis and Cox proportional hazard models to examine the association between deprivation, ethnicity and maternal age and pertussis vaccination in pregnancy and children's MMR uptake. RESULTS: Overall, 89.4 % (710,797/795,497) of children had first MMR by age 2 years and 92.6 % (736,495/795,497) by age 5 years. Among children still in the cohort when second MMR was due, 85.9 % (478,480/557,050) had two MMRs by age 5 years. Children from the most-deprived areas, children of Black ethnicity and children of mothers aged < 20 years had increased risk of being unvaccinated compared with children from the least-deprived areas, White children and children of mothers aged 31-40 years: first MMR by 5 years, adjusted Hazard Ratios (HR):0.86 (CI:0.85-0.87), HR:0.87 (CI:0.85-0.88) & HR:0.89 (CI:0.88-0.90) respectively. Deprivation was the determinant associated with the greatest risk of missed second MMR: adjusted HR:0.82 (CI:0.81-0.83). Children of mothers vaccinated in pregnancy were more likely than children of unvaccinated mothers to have MMR vaccines after adjusting for ethnicity, deprivation, and maternal age (First and Second MMRs adjusted HRs:1.43 (CI:1.41-1.45), 1.49 (CI:1.45-1.53). CONCLUSION: Children from most-deprived areas are less likely to have MMR vaccines compared with children from least-deprived areas. Mothers who take up pregnancy vaccines are more likely to have their children vaccinated with MMR. Healthcare services should promote and facilitate access to both maternal and childhood vaccines during pregnancy. |
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| ジャーナル名 | Vaccine |
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| 投稿日 | 2023/12/11 |
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| 投稿者 | Skirrow, H; Foley, K; Bedford, H; Lewis, C; Whittaker, E; Costelloe, C; Saxena, S |
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| 組織名 | School of Public Health, Imperial College London, United Kingdom. Electronic;address: h.skirrow@imperial.ac.uk.;School of Public Health, Imperial College London, United Kingdom.;Population, Policy and Practice, Great Ormond Street Institute of Child Health,;University College London, United Kingdom.;University College London, United Kingdom; London North Genomic Laboratory Hub,;Great Ormond Street Hospital, London, United Kingdom.;Section of Paediatric Infectious Diseases, Imperial College London, United;Kingdom; Department of Paediatric Infectious Diseases, Imperial College;Healthcare NHS Trust, United Kingdom.;School of Public Health, Imperial College London, United Kingdom; Institute of;Cancer Research, London, United Kingdom. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38072757/ |
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