| アブストラクト | The benefit of using adjunctive intravenous steroids (IVS) to reduce the neurological sequelae in bacterial meningitis remains inconclusive. This study evaluated the effect of IVS on improving the subsequent Activities of Daily Living (ADL) in bacterial meningitis by analyzing data from a large nationwide administrative medical database in Japan. Data from 1,132 hospitals, covered by the administrative Diagnosis Procedure Combination (DPC) payment system from 2016 to 2022, were evaluated. The ADL levels at admission and discharge were measured using the Barthel Index (BI). Out of the cumulative 47,366,222 patients hospitalized, 8,736 were diagnosed with acute bacterial meningitis and had BI data available. The BI at discharge, adjusted for sex, age, and BI at admission, was significantly better among those treated with IVS (p<0.0001). Exploratory subgroup analyses suggested that this benefit is expected across a broad spectrum of bacterial species. In summary, the use of IVS for improving the subsequent ADL level in bacterial meningitis was suggested. |
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| ジャーナル名 | Cureus |
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| 投稿日 | 2024/3/18 |
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| 投稿者 | Akaishi, Tetsuya; Tarasawa, Kunio; Fushimi, Kiyohide; Yaegashi, Nobuo; Aoki, Masashi; Fujimori, Kenji |
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| 組織名 | Department of Education and Support for Regional Medicine, Tohoku University;Hospital, Sendai, JPN.;Department of Health Administration and Policy, Tohoku University Hospital,;Sendai, JPN.;Department of Health Policy and Informatics, Tokyo Medical and Dental University,;Tokyo, JPN.;Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, JPN.;Department of Neurology, Tohoku University Hospital, Sendai, JPN. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38496109/ |
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