| アブストラクト | Improving adverse drug event (ADE) prediction is highly critical in pharmacovigilance research. We propose a novel information component guided pharmacological network model (IC-PNM) to predict drug-ADE signals. This new method combines the pharmacological network model and information component, a Bayes statistics method. We use 33,947 drug-ADE pairs from the FDA Adverse Event Reporting System (FAERS) 2010 data as the training data, and the new 21,065 drug-ADE pairs from FAERS 2011-2015 as the validations samples. The IC-PNM data analysis suggests that both large and small sample size drug-ADE pairs are needed in training the predictive model for its prediction performance to reach an area under the receiver operating characteristic curve [Formula: see text]. On the other hand, the IC-PNM prediction performance improved to [Formula: see text] if we removed the small sample size drug-ADE pairs from the prediction model during validation. |
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| ジャーナル名 | IEEE/ACM transactions on computational biology and bioinformatics |
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| 投稿日 | 2019/8/24 |
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| 投稿者 | Ji, Xiangmin; Wang, Lei; Hua, Liyan; Wang, Xueying; Zhang, Pengyue; Shendre, Aditi; Feng, Weixing; Li, Jin; Li, Lang |
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| 組織名 | |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31443040/ |
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