| アブストラクト | BACKGROUND: Dopamine receptor agonist drugs, which are used, for example, to treat Parkinson's disease (PD), increase the risk for impulse control disorders (ICDs), potentially resulting in devastating psychosocial consequences. It is unknown whether other drugs with dopaminergic properties also increase the risk for ICDs. This study assesses the disproportionality of reporting ICDs between drugs with dopaminergic properties and selected non-dopaminergic drugs. METHODS: A case/non-case disproportionality analysis was performed, using data from VigiBase (1968-2020). Reports on ICDs as suspected adverse drug reactions (ADRs) were cases (n=852), and those with ADRs other than ICDs were non-cases (n=281,720). Relative reporting frequencies were expressed as adjusted reporting odds ratios (aRORs). Within the dopamine receptor agonists, the relationship between reporting odds ratios and dopamine receptor occupancy was explored. RESULTS: A high disproportionality was found for reporting ICDs for all dopaminergic drugs (aROR 20.4 [95% CI 17.4-24.1]) compared to non-dopaminergic drugs. In pharmacotherapeutic subgroups, a high disproportionality was found for primary dopaminergic agents used in PD (aROR 52.1 [95% CI 44.1-61.5]), and to a lesser extent for ADHD psychostimulants and antidepressants (aROR 5.8 [95% 4.1-8.3] and aROR 3.9 [95% CI 2.9-5.6], respectively). There was no difference in reporting by consumers and healthcare professionals. The highest disproportionality was found for the dopamine receptor agonists pramipexole and ropinirole. CONCLUSIONS: A signal of disproportion in ICD occurrence was found among all investigated drugs with dopaminergic properties, highlighting the importance of counselling and monitoring for ICDs when prescribing dopaminergic drugs. |
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| ジャーナル名 | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology |
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| 投稿日 | 2022/2/22 |
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| 投稿者 | De Wit, Laura E; Wilting, Ingeborg; Souverein, Patrick C; van der Pol, Peggy; Egberts, Toine C G |
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| 組織名 | Dept. of Psychiatry, University Medical Center Utrecht, the Netherlands; Dept. of;Psychiatry, Sint Antonius Hospital, Utrecht, the Netherlands. Electronic address:;L.E.deWit-2@umcutrecht.nl.;Dept. of Clinical Pharmacy, University Medical Center Utrecht, the Netherlands.;Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for;Pharmaceutical Siences, Utrecht University, the Netherlands.;Topicus Healthcare, Wageningen, the Netherlands.;Dept. of Clinical Pharmacy, University Medical Center Utrecht, the Netherlands; |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35189453/ |
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