| アブストラクト | AIMS: To estimate the frequency of childhood retinoblastoma among children conceived by in vitro fertilization (IVF). METHODS: Using the United Kingdom-based General Practice Research Database (GPRD), we identified all live births, cases of retinoblastoma and IVF procedures occurring between January 1989 and December 2001. RESULTS: We identified 0 cases of retinoblastoma among 176 children conceived by IVF (Risk = 0/176, one-sided 97.5% CI 0, 0.02) and 24 cases of retinoblastoma diagnosed before age 5 years among 358,094 children not conceived by IVF (6.7 cases per 100,000 births [95% CI 4.5, 10]). CONCLUSIONS: These data provide some reassurance that children born as a result of IVF are not at markedly increased risk of retinoblastoma. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| Pubmed追加日 | 2004/07/17 |
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| 投稿者 | Bradbury, Brian D; Jick, Hershel |
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| 組織名 | The Boston Collaborative Drug Surveillance Program, Boston University School of;Medicine, 11 Muzzey Street, Lexington, MA 02421, USA. bdb2@bu.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/15255804/ |
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