| アブストラクト | This study aimed to estimate the incidence and prognosis of neonatal disseminated intravascular coagulation (DIC) in Japan by analyzing data retrieved from a national administrative database. Clinically, the prognosis of DIC in neonates is poor, but there is little epidemiological data in Japan. This retrospective observational study identi fi ed patients diagnosed with neonatal DIC and who were registered in the Japanese diagnosis procedure combination (DPC) database between April 1, 2014 and March 31, 2016. The patients, who were diagnosed with neonatal DIC, included those with ICD-10 code D65 or P60 in primary and secondary diagnosis, with comorbid conditions existing at admission, and with complications occurring after admission. Of 78,073 neonates admitted to 1,474 neonatal intensive care units, 1,864 (2.4%) were diagnosed with DIC. There was no difference between sexes in incidence of DIC; the incidence of DIC was higher in extremely low birth weight infants (9.8%), and significantly higher than that in normal birth weight infants. The overall mean length of hospital stay was longer in neonates with DIC (69.5 days) than in those without DIC (32.6 days, P < 0.001). The number of deaths was 1,156 (1.5%). In-hospital mortality was significantly higher in neonates with DIC (14.1%) than in those without DIC (1.2%, P < 0.001), especially in premature babies. This nationwide study was the first report to investigate the incidence and in-hospital mortality of neonatal DIC in Japan. Neonatal DIC has a significant impact on prognosis, and its influence is greater in premature than in term infants. |
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| ジャーナル名 | Journal of UOEH |
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| 投稿日 | 2019/9/25 |
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| 投稿者 | Araki, Shunsuke; Tomioka, Shinichi; Otani, Makoto; Suga, Shutaro; Ichikawa, Shun; Matsuda, Shinya; Fushimi, Kiyohide; Kusuhara, Koichi; Shirahata, Akira |
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| 組織名 | Department of Pediatrics, School of Medicine, University of Occupational and;Environmental Health, Japan.;Department of Preventive Medicine and Community Health, School of Medicine,;University of Occupational and Environmental Health, Japan.;Occupational Health Data Science Center, School of Medicine, University of;Occupational and Environmental Health, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School.;Kitakyushu Yahata Higashi Hospital. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31548484/ |
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