| アブストラクト | This study evaluates the incidence and characteristics of adverse events (AEs) following the second COVID-19 booster dose, leveraging Taiwan's distinctive approach of extending booster vaccinations to all citizens, unlike the targeted high-risk group strategies in other countries. Utilizing data from Taipei Veterans General Hospital's Vaccine Adverse Event Reporting System (VAERS) from 27 October 2022 to 19 January 2023, this research examines AEs in 441 out of 1711 booster recipients, considering factors like age, vaccine brands, and booster combinations. The findings revealed incidence rates (IRs) of 25.6% (95% CI: 21.1-30.8) after the first booster and 24.9% (95% CI: 20.5-30.0) after the second, mostly non-serious, with those having AEs post-first booster being five times more likely to report them again (incidence rate ratio, 5.02, p < 0.001). Significantly, switching from the mRNA1273 vaccine to another brand reduced AE risk by 18%. This study underscores that AEs are more repetitive than cumulative with additional booster doses, advocating for personalized vaccination strategies based on individual medical histories and previous vaccine reactions. These insights are valuable for healthcare providers in discussing potential AEs with patients, thereby improving vaccine compliance and public trust, and for policymakers in planning future booster vaccination strategies. |
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| ジャーナル名 | Vaccines |
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| 投稿日 | 2024/2/24 |
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| 投稿者 | Lin, Ching-Hao; Chen, Tsung-An; Chiang, Pin-Hsuan; Hsieh, Ai-Ru; Wu, Bih-Ju; Chen, Po-Yu; Lin, Kuan-Chen; Tsai, Zih-Syun; Lin, Ming-Hwai; Chen, Tzeng-Ji; Chen, Yu-Chun |
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| 組織名 | Department of Family Medicine, Taipei Veterans General Hospital, Taipei 112,;Taiwan.;Big Data Center, Taipei Veterans General Hospital, Taipei 112, Taiwan.;Department of Statistics, Tamkang University, New Taipei City 251, Taiwan.;Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan.;Department of Family Medicine, Cheng Hsin General Hospital, Taipei 112, Taiwan.;School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.;Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu Branch,;Hsinchu 31064, Taiwan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38400133/ |
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