| アブストラクト | To clarify the association between carboplatin and electrolyte abnormality, a pooled-analysis was performed with the adverse event reports of non-small cell lung cancer patients. A total of 19901 adverse events were retrieved from the FDA Adverse Event Reporting System (FAERS). Pooled reporting odds ratios (RORs) and 95% CIs suggested that carboplatin was significantly associated with hyponatremia (pooled ROR = 1.57, 95% CI 1.18-2.09, P = 1.99x10-3) and hypokalemia (pooled ROR = 2.37, 95% CI 1.80-3.10, P = 5.24x10-10) as compared to other therapies. In addition, we found that dehydration was frequently concurrent with carboplatin therapy (pooled ROR = 2.01, 95% CI 1.52-2.66, P = 8.37x10-7), which may prompt excessive water ingestion and decrease serum electrolyte concentrations. This information has not been mentioned in the FDA-approved drug label and could help explain the physiological mechanism of carboplatin-induced electrolyte abnormality. In conclusion, the above results will facilitate clinical management and prompt intervention of life-threatening electrolyte imbalance in the course of cancer treatment. |
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| ジャーナル名 | Oncotarget |
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| 投稿日 | 2016/10/27 |
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| 投稿者 | Ma, Yushui; Hou, Likun; Yu, Fei; Lu, Gaixia; Qin, Shanshan; Xie, Ruting; Yang, Huiqiong; Wu, Tingmiao; Luo, Pei; Chai, Li; Lv, Zhongwei; Peng, Xiaodong; Wu, Chunyan; Fu, Da |
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| 組織名 | Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji;University School of Medicine, Shanghai, China.;Shanghai Engineering Research Center of Molecular Therapeutics and New Drug;Development, College of Chemistry and Molecular Engineering, East China Normal;University, Shanghai, China.;Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of;Medicine, Shanghai, China.;Department of Pathology, Shanghai Tenth People's Hospital, Tongji University;School of Medicine, Shanghai, China.;Department of Oncology, the First Affiliated Hospital of Nanchang University.;Nanchang, China.;Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27780935/ |
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