| アブストラクト | AIMS: To quantify nationwide incidence and contemporary treatment patterns of acute retinal necrosis (ARN). METHODS: Retrospective cohort using Japan's National Database of Health Insurance Claims and Specific Health Checkups, which covers >95% of claims. New-onset ARN (2016-2022) was identified by ARN diagnostic codes plus antiviral therapy. Annual, age-specific and sex-specific incidence rates used governmental denominators; age-standardised rates used the WHO world standard. Surgical management (vitreoretinal surgery, silicone oil (SO)/perfluorocarbon (PFC) use, glaucoma surgery) was assessed up to 2 years after diagnosis. RESULTS: Among 586 incident cases (313 men, 273 women), crude incidence was 0.066 (95% CI 0.061 to 0.072) per 100 000 person-years; the age-standardised rate was 0.040 per 100 000 person-years. Incidence rose with age, peaking at 70-74 years, and was consistently higher in men than in women. Vitreoretinal surgery occurred in 42.4% by 30 days and 59.4% by 365 days after diagnosis; 25.1% underwent >/=2 procedures within 1 year. SO or PFC was used in 40.8% by 1 year. Glaucoma surgery was uncommon (<2% by 2 years). CONCLUSION: In the largest population-based study of ARN to date, nationwide incidence in Japan closely matched prior UK estimates, suggesting cross-system consistency in ARN epidemiology. Management was characterised by early, intensive surgery with frequent tamponade use and substantial reoperation, informing clinical triage and resource planning for this rare, vision-threatening condition. |
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| ジャーナル名 | The British journal of ophthalmology |
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| Pubmed追加日 | 2026/2/13 |
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| 投稿者 | Akada, Masahiro; Hata, Masayuki; Muraoka, Yuki; Ishihara, Kenji; Kadomoto, Shin; Ueshima, Hiroaki; Tamura, Hiroshi; Tsujikawa, Akitaka; Miyake, Masahiro; Usui, Yoshihiko |
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| 組織名 | Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School;of Medicine, Kyoto, Japan.;Center for Innovative Research and Education in Data Science, Institute for;Liberal Arts and Sciences, Kyoto University, Kyoto, Japan.;of Medicine, Kyoto, Japan miyakem@kuhp.kyoto-u.ac.jp.;Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41679958/ |
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