| アブストラクト | Background Paediatric otorrhoea (PO) is a symptom-based diagnosis encompassing acute and chronic ear infections which cause otorrhoea in children and young people (CYP). Aim To understand the burden of PO on primary care services. Design and Setting A longitudinal population study in UK primary care. Methods Data from the Clinical Practice Research Datalink (CPRD Aurum), January 2005 to December 2019, was analysed. CYP under 17 years of age with otorrhoea were included. Standardised annual incidence and presentation rates were estimated. Poisson regression modelling was used to determine risk ratios comparing sex, age and IMD. A probabilistic simulation scaled-up estimates for the UK population. Results The cohort included 6,605,193 CYP, observed over 32,942,594 person-years. There were 80,454 incident cases and 106,318 presentations of PO during the 15-year period, equating to standardised annual incidence and presentation rates per 1000 patient-years of 2.42 (95% CI: 2.40-2.44) and 3.15 (3.13-3.17) respectively. In the UK this equates to 41,141 primary care appointments per year. Incidence was higher in males, those aged 0-2 years, and those living in the least deprived quintile. Treatment involved oral antibiotics (57.1%), no prescription (28.1%), topical antibiotics (9.7%), or combination (4.9%). The cost to NHS primary care is estimated at pound1.97 million per year. Conclusions This is the first longitudinal population-based study investigating PO which demonstrates the burden on primary care. Antimicrobial prescribing predominantly follows NICE guidelines using oral amoxicillin. Aminoglycosides are the most frequently prescribed topical antibiotic despite the concern of ototoxicity. |
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| ジャーナル名 | The British journal of general practice : the journal of the Royal College of General Practitioners |
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| 投稿日 | 2024/8/21 |
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| 投稿者 | Heward, Elliot; Domzaridou, Eleni; Gavan, Sean P; Carr, Matthew J; Lunn, Judith; Molloy, John; Isba, Rachel; Hay, Alastair D; Nichani, Jaya R; Bruce, Iain A; Ashcroft, Darren |
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| 組織名 | Manchester University NHS Foundation Trust, Royal Manchester Children's Hospital,;Manchester, United Kingdom elliotheward@doctors.org.uk.;The University of Manchester, Division of Infection, Immunity and Respiratory;Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health,;Manchester, United Kingdom.;The University of Manchester, Division of Pharmacy & Optometry, School of Health;Sciences, Faculty of Biology, Medicine and Health, Manchester, United Kingdom.;The University of Manchester, NIHR Greater Manchester Patient Safety Research;Collaboration (PSRC), Manchester, United Kingdom.;The University of Manchester, Manchester Centre for Health Economics, Division of;Population Health, Health Services Research and Primary Care, School of Health;Lancaster University, Lancaster Medical School, Lancaster, United Kingdom.;Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.;University of Bristol, Centre for Academic Primary Care, Bristol Medical School:;Population Health Sciences, Bristol, United Kingdom. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39164028/ |
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