| アブストラクト | Diagnosing cancer may be expedited by decreasing referral risk threshold. Clinical Practice Research Datalink participants (>/=40 years) had a positive predictive value (PPV) >/=3% feature for breast, lung, colorectal, oesophagogastric, pancreatic, renal, bladder, prostatic, ovarian, endometrial or laryngeal cancer in 2016. The numbers of participants with features representing a 1-1.99% or 2-2.99% PPV for same cancer in the previous year were reported, alongside the time difference between meeting the >/=3% criteria and the lower threshold criteria. A total of 8616 participants had a PPV >/=3% feature, of whom 365 (4.2%) and 1147 (13.3%), respectively, met 2-2.99% and 1-1.99% criteria in the preceding year. The median time difference was 131 days (Interquartile Range (IQR) 27 to 256) for the 2-2.99% band and 179 days (IQR 58 to 289) for the 1-1.99% band. Results were heterogeneous across cancer sites. For some cancers, participants may progress from presenting lower- to higher-risk features before meeting urgent referral criteria; however, this was not usually the case. The details of specific features across multiple cancer sites will allow for a tailored approach to future reductions in referral thresholds, potentially improving the efficiency of urgent cancer referrals for the benefit both of individuals and the National Health Service (NHS). |
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| ジャーナル名 | Cancers |
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| Pubmed追加日 | 2023/8/12 |
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| 投稿者 | Moore, Sarah F; Price, Sarah J; Bostock, Jennifer; Neal, Richard D; Hamilton, Willie |
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| 組織名 | Faculty of Health and Life Sciences, University of Exeter, Exeter EX2 4TH, UK.;Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis, Queen;Mary University of London, Mile End Rd., London E1 4NS, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37568751/ |
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