| アブストラクト | BACKGROUND: A rising incidence and high mortality were found for bullous pemphigoid (BP) over a decade ago in the UK. Updated estimates of its epidemiology are required to understand the healthcare needs of an ageing population. OBJECTIVES: To determine the incidence, prevalence and mortality rates of BP in England from 1998 to 2017. METHODS: We conducted a cohort study of longitudinal electronic health records using the Clinical Practice Research Datalink and linked Hospital Episode Statistics. Incidence was calculated per 100 000 person-years and annual point prevalence per 100 000 people. Multivariate analysis was used to determine incidence rate ratios by sociodemographic factors. Mortality was examined in an age-, sex- and practice-matched cohort, using linked Office of National Statistics death records. Hazard ratios (HRs) were stratified by matched set. RESULTS: The incidence was 7.63 [95% confidence interval (CI) 7.35-7.93] per 100 000 person-years and rose with increasing age, particularly for elderly men. The annual increase in incidence was 0.9% (95% CI 0.2-1.7). The prevalence almost doubled over the observation period, reaching 47.99 (95% CI 43.09-53.46) per 100 000 people and 141.24 (95% CI 125.55-158.87) per 100 000 people over the age of 60 years. The risk of all-cause mortality was highest in the 2 years after diagnosis (HR 2.96; 95% CI 2.68-3.26) and remained raised thereafter (HR 1.54; 95% CI 1.36-1.74). CONCLUSIONS: We report a modest increase in the incidence rate of BP, but show that the burden of disease in the elderly population is considerable. Mortality is high, particularly in the first 2 years after diagnosis. |
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| ジャーナル名 | The British journal of dermatology |
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| Pubmed追加日 | 2020/3/10 |
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| 投稿者 | Persson, M S M; Harman, K E; Vinogradova, Y; Langan, S M; Hippisley-Cox, J; Thomas, K S; Gran, S |
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| 組織名 | Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.;Division of Primary Care, University of Nottingham, Nottingham, UK.;Department of Non-communicable Disease Epidemiology, London School of Hygiene and;Tropical Medicine, London, UK.;Nuffield Department of Primary Care Health Sciences, University of Oxford,;Oxford, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32147814/ |
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