| アブストラクト | BACKGROUND AND PURPOSE: Data on rates of newly diagnosed depression after multiple sclerosis (MS) diagnosis are sparse. Here, incident, treated depression in MS patients after diagnosis compared with matched non-MS patients is described. METHODS: A matched cohort study was conducted in two separate electronic medical databases: the US Department of Defense (US-DOD) military healthcare system and the UK's Clinical Practice Research Datalink GOLD (UK-CPRD). The study population included all patients with a first recorded diagnosis of MS and matched non-MS patients. Patients with a history of treated depression were excluded. Incidence rates and incidence rate ratios with 95% confidence intervals for treated depression after MS diagnosis/matched date were estimated. RESULTS: Incidence rate ratios of treated depression amongst MS patients compared with non-MS patients were 3.20 (95% confidence interval 3.05-3.35) in the US-DOD and 1.90 (95% confidence interval 1.74-2.06) in the UK-CPRD. Incidence rate ratios were elevated across age and sex. Rates were higher in females than males but, compared to non-MS patients, males with MS had a higher relative risk than females with MS. CONCLUSIONS: Multiple sclerosis patients in the UK and the USA have a two- to three-fold increased risk of new, treated depression compared to matched non-MS patients. |
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| 投稿者 | Persson, R; Lee, S; Yood, M U; Wagner, M R; Minton, N; Niemcryk, S; Lindholm, A; Evans, A M; Jick, S |
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| 組織名 | Epidemiology, Boston Collaborative Drug Surveillance Program, Lexington, MA, USA.;Drug Safety, Celgene Corporation, Summit, NJ, USA.;Chief Scientific Officer, EpiSource LLC, Newton, MA, USA.;Boston University School of Public Health, Boston, MA, USA.;Department of Neurology, Naval Medical Center Portsmouth, Portsmouth, VA, USA.;Epidemiology, Health ResearchTx LLC, Trevose, PA, USA. |
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