| アブストラクト | Urinary tract infection (UTI) and pyelonephritis cause urosepsis, which can become life threating. Sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors, a class of oral anti-diabetic drugs, may increase the risk of UTI and pyelonephritis, as observed from their mechanism of action. Patients with diabetes receiving SGLT2 inhibitors are often concomitantly administered other antidiabetic, antidyslipidemic, or antihypertensive drugs. To determine if drug-drug interactions (DDIs) between SGLT2 inhibitors and these medications increased the risk of UTI and pyelonephritis, we analyzed the Food and Drug Administration Adverse Event Reporting System (FAERS) database. We applied Noren's and Gosho's methods for detecting DDIs. FAERS contains records describing 14 526 398 patient characteristics, 54 290 663 drug properties, and 47 252 416 reactions/events. We found 23 drug combinations that could induce UTI and pyelonephritis, such as SGLT2 inhibitors administered with dipeptidyl peptidase-4 inhibitors, thiazolidinediones, glinides, statins, angiotensin II receptor blockers, and calcium channel blockers. Combination therapy with the drugs detected in our analyses would show potential interactions that could result in UTI and pyelonephritis in patients with diabetes mellitus. However, owing to various limitations, these results must be confirmed by additional analyses. |
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| ジャーナル名 | Fundamental & clinical pharmacology |
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| 投稿日 | 2022/4/30 |
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| 投稿者 | Tada, Keisuke; Gosho, Masahiko |
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| 組織名 | Biostatistics & Programming, Sanofi K.K, Tokyo Opera City Tower, Tokyo, Japan.;Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki,;Japan.;Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Ibaraki, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35484899/ |
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