| アブストラクト | OBJECTIVE: To determine whether the incidence of atrial fibrillation (AF) is static or rising in the UK. DESIGN: Among the cohort of all individuals aged >/=45 years in the UK Clinical Practice Research Datalink (CPRD) (linked to hospital discharges) we identified incident non-valvular AF cases between 2001 and 2013. Overall and annual AF incidence rates were calculated and standardised to the UK population. RESULTS: The cohort of 2.23 million individuals included 91,707 patients with incident AF. The overall standardised AF incidence rate was 6.7 (95% CI 6.7 to 6.8) per 1000 person-years, increasing exponentially with age and higher in men of all ages. There was a small increase in the standardised incidence of AF in the last decade from 5.9 (5.8 to 6.1)/1000 person-years in 2001 to 6.9 (6.8 to 7.1)/1000 person-years in 2013, mostly attributable to subjects aged >80 years with a non-primary hospital discharge diagnosis of AF. Standardised incidence rates of AF among white patients was 8.1 (8.1 to 8.2)/1000 person-years, compared with 5.4 (4.6 to 6.3) for Asians and 4.6 (4.0 to 5.3) for black patients. AF diagnosis was first made in general practice in 39% of incident AF. CONCLUSIONS: The incidence of AF in the UK has increased gradually in the last decade, with more than 200 000 first-ever non-valvular AF cases expected in 2015. This increase is only partly due to population ageing, though the principal increase has been in the elderly hospitalised for a reason other than AF. |
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| ジャーナル名 | Heart (British Cardiac Society) |
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| 投稿日 | 2015/08/27 |
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| 投稿者 | Martinez, Carlos; Katholing, Anja; Wallenhorst, Christopher; Granziera, Serena; Cohen, Alexander T; Freedman, Saul Benedict |
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| 組織名 | Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany.;Department of Medicine, University hospital of Padua, Padua, Italy.;Department of Haematology, Guy's and St Thomas' Hospitals, King's College,;London, UK.;Department of Cardiology, Sydney Medical School, University of Sydney, Dept of;Cardiology Concord Hospital and Anzac Research Institute, Sydney, Australia. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26307057/ |
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