| アブストラクト | BACKGROUND: Annually, one in four UK adults experience common mental disorders (CMD), (i.e., anxiety or depression). While central nervous system infections are associated with an increased CMD risk, the relationship between other infections and CMD is unclear. METHODS: We conducted six matched cohort studies using data from the Clinical Practice Research Datalink Aurum (01/01/2007-15/06/2024). Adults (>/=18 years) with skin/soft tissue (SSTI), lower respiratory tract (LRTI) and urinary tract (UTI) infections, gastroenteritis (GE), sepsis, and meningitis/encephalitis (positive control exposure) were matched on sex, age, general practice, and calendar period with up to five adults without that infection. We used Cox regression, stratified by matched set, adjusted for deprivation, Charlson comorbidity index, alcohol, smoking, body mass index, and ethnicity to estimate hazard ratios (HRs) for incident CMD comparing adults with and without infection. OUTCOMES: Numbers of individuals included in infection-specific cohorts ranged from 13,196 with meningitis/encephalitis matched to 54,946 without, to 304,770 individuals with SSTI matched to 1,130,070 without. Median follow-up ranged from 3.8 years (interquartile range [IQR]: 1.7,6.6) in the sepsis cohort, to 5.0 years (IQR: 2.0,9.3) in the LRTI cohort. Median age ranged from 44 years (IQR: 30,63) in the meningitis/encephalitis cohort to 74 (IQR 62,83) in the sepsis cohort; 44-52% of all cohorts were women, except for the UTI cohort (76% women). After adjustment, each infection was associated with increased risk of CMD, ranging from HR 1.29(95%CI 1.28, 1.31) for SSTI, to HR 1.58 (95%CI 1.55,1.61) for sepsis. INTERPRETATION: Our findings suggest adults with acute infections are at greater risk of CMD than adults without infection. Evidence was stronger for more severe infections (e.g., sepsis). Mental health screening and intervention during and after infections, timely infection treatment and vaccination, may improve mental health. |
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| 投稿者 | Gore-Langton, Georgia R; Cadogan, Sharon L; Mansfield, Kathryn E; Douglas, Ian; Fazel, Seena; Tazare, John; Morton, Caroline; Mukadam, Naaheed; Warren-Gash, Charlotte |
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| 組織名 | Faculty of Epidemiology and Population Health, London School of Hygiene and;Tropical Medicine, London, UK. Electronic address:;georgia.gore-langton@lshtm.ac.uk.;Tropical Medicine, London, UK.;School of Health and Care Sciences, University of Lincoln, Lincoln, UK.;Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS;Foundation Trust, Oxford, UK.;Division of Psychiatry, University College London, London, UK. |
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