| アブストラクト | BACKGROUND: Previous studies suggested a link between various infectious pathogens and the development of Alzheimer's disease (AD), posing the question whether infectious disease could present a novel modifiable risk factor. OBJECTIVE: To assess whether infectious disease burden due to clinically apparent infections is associated with an increased risk of AD. METHODS: We conducted a population-based nested case-control study using the United Kingdom Clinical Practice Research Datalink. We included all dementia-free subjects >/=50 years of age enrolling in the database between January 1988 and December 2017. Each case of AD identified during follow-up was matched with up to 40 controls. Conditional logistic regression estimated adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of AD associated with >/=1 infection diagnosed > 2 years before the index date compared with no infection during the study period. We further stratified by time since first infection and cumulative number of infections. RESULTS: The cohort included overall 4,262,092 individuals (mean age at cohort entry 60.4 years; 52% female). During a median follow-up of 10.5 years, 40,455 cases of AD were matched to 1,610,502 controls. Compared with having no burden of infectious disease, having a burden of infectious disease was associated with an increase in the risk of AD (OR, 1.05; 95% CI, 1.02 to 1.08). The risk increased with longer time since first infection, peaking after 12-30 years (OR, 1.11; 95% CI, 1.05-1.17). The risk did not increase with cumulative number of infections. CONCLUSION: The overall risk of AD associated with infectious disease burden was small but increased gradually with longer time since first infection. |
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| ジャーナル名 | Journal of Alzheimer's disease : JAD |
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| 投稿日 | 2021/3/30 |
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| 投稿者 | Douros, Antonios; Santella, Christina; Dell'Aniello, Sophie; Azoulay, Laurent; Renoux, Christel; Suissa, Samy; Brassard, Paul |
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| 組織名 | Department of Medicine, McGill University, Montreal, QC, Canada.;Department of Epidemiology, Biostatistics, and Occupational Health, McGill;University, Montreal, QC, Canada.;Centre for Clinical Epidemiology, Lady Davis Institute, Montreal, QC, Canada.;Institute of Clinical Pharmacology and Toxicology, Charite - Universitatsmedizin;Berlin, Berlin, Germany.;Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.;Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec,;Canada. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33780369/ |
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