| アブストラクト | Although diuretics play an important role in triple-whammy acute kidney injury (AKI), it is unclear whether the type of diuretic influences the risk of triple-whammy AKI. The aim of this study was to evaluate whether vasopressin receptor antagonists affect triple-whammy AKI. This cross-sectional study used disproportionality analysis of VigiBase data to assess the risk of AKI with various diuretics. Although multiple logistic regression analysis showed that aldosterone antagonists (odds ratio [OR] 2.19, 95% CI 2.01-2.37), loop diuretics (OR 4.40, 95% CI 4.07-4.76) and thiazide diuretics (OR 1.98, 95% CI 1.83-2.15) increased the risk of AKI in patients who received non-steroidal anti-inflammatory drugs (NSAIDs) and renin-angiotensin system inhibitors (RASi), vasopressin receptor antagonists did not increase the risk of AKI in those patients. Vasopressin receptor antagonists might not influence the development of triple-whammy AKI. |
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| 投稿者 | Mitsuboshi, Satoru; Hayakawa, Kenji; Hamano, Hirofumi; Oshima, Ayako; Takeda, Tatsuaki; Murakawa, Kiminaka; Mori, Hideki; Zamami, Yoshito |
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| 組織名 | Department of Pharmacy, Kaetsu Hospital, Niigata, Japan.;Department of Pharmacy, Tachikawa General Hospital, Niigata, Japan.;Department of Pharmacy, Okayama University Hospital, Okayama, Japan.;Department of Clinical Pharmacology and Pharmacy, Okayama University, Okayama,;Japan.;Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama,;Department of Health Data Science, Okayama University, Okayama, Japan.;Department of Pharmacy, Japanese Red Cross Okayama Hospital, Okayama, Japan. |
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