| アブストラクト | Influenza is rarely laboratory-confirmed and the outpatient influenza burden is rarely studied due to a lack of suitable data. We used the Clinical Practice Research Datalink (CPRD) and surveillance data from Public Health England in a linear regression model to assess the number of persons consulting UK general practitioners (GP episodes) for respiratory illness, otitis media and antibiotic prescriptions attributable to influenza during 14 seasons, 1995-2009. In CPRD we ascertained influenza vaccination status in each season and risk status (conditions associated with severe influenza outcomes). Seasonal mean estimates of influenza-attributable GP episodes in the UK were 857 996 for respiratory disease including 68 777 for otitis media, with wide inter-seasonal variability. In an average season, 2.4%/0.5% of children aged <5 years and 1.3%/0.1% of seniors aged 75 years had a GP episode for respiratory illness attributed to influenza A/B. Two-thirds of influenza-attributable GP episodes were estimated to result in prescription of antibiotics. These estimates are substantially greater than those derived from clinically reported influenza-like illness in surveillance programmes. Because health service costs of influenza are largely borne in general practice, these are important findings for cost-benefit assessment of influenza vaccination programmes. |
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| ジャーナル名 | Epidemiology and infection |
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| 投稿日 | 2015/07/15 |
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| 投稿者 | Fleming, D M; Taylor, R J; Haguinet, F; Schuck-Paim, C; Logie, J; Webb, D J; Lustig, R L; Matias, G |
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| 組織名 | 9 Dowles Close,Birmingham,UK(independent consultant).;Sage Analytica,Bethesda,MD,USA.;GSK Vaccines,Wavre,Belgium.;GSK R&D,Uxbridge,Middlesex,UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26168005/ |
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