| アブストラクト | INTRODUCTION: In patients with COPD who have recently been hospitalized for their disease, we examined whether treatment with inhaled corticosteroids without or with long-acting beta-adrenoceptor agonists (beta-agonists) reduced rehospitalization and mortality. STUDY DESIGN: Retrospective cohort analysis in the UK General Practice Research Database. METHODS: We compared rehospitalization for a COPD-related medical condition or death within 1 year after first hospitalization, in 3636 COPD patients receiving prescriptions for inhaled corticosteroids or long-acting beta-agonists compared with 627 reference patients with COPD who were prescribed short-acting bronchodilators only. RESULTS: Rehospitalization within a year occurred in 13.2% of the reference COPD patients, 14.0% of users of long-acting beta-agonists only, 12.3% of users of inhaled corticosteroids only, and 10.4% of users of inhaled corticosteroids and long-acting beta-agonists. Death within a year occurred in 24.3% of the reference COPD patients, 17.3% of users of long-acting beta-agonists only, 17.1% of users of inhaled corticosteroids only, and in 10.5% of users of inhaled corticosteroids and long-acting beta-agonists. In multivariate analyses the risk of rehospitalization or death was reduced by 10% in users of long-acting beta-agonists only (NS), by 16% in users of inhaled corticosteroids only, and by 41% in users of combined inhaled corticosteroids and long-acting beta-agonists (both p < 0.05). CONCLUSION: Use of inhaled corticosteroids with/without long-acting beta-agonists was associated with a reduction of rehospitalization or death in COPD patients. |
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| ジャーナル名 | American journal of respiratory medicine : drugs, devices, and other interventions |
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| Pubmed追加日 | 2004/1/15 |
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| 投稿者 | Soriano, Joan B; Kiri, Victor A; Pride, Neil B; Vestbo, Jorgen |
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| 組織名 | Worldwide Epidemiology, GlaxoSmithKline Research and Development, Greenford, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/14720023/ |
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