| アブストラクト | BACKGROUND: Insomnia is one of the most prevalent diseases observed in clinical practice, contributing to increased death and a range of chronic diseases. While numerous studies have explored the relationship between insomnia and cardiovascular disease, research on its association with atrial fibrillation (AF) remains limited. This study aimed to investigate the association between insomnia and incident AF in the general population by comprehensive, nationwide, real-world data in Japan. METHODS: A total of 1 780 764 individuals without prior cardiovascular disease including AF from the DeSC database were included between April 2014 and August 2023. Insomnia was defined by International Classification of Diseases, Tenth Revision (ICD-10) codes (F510, G470) before the baseline health checkup. The primary outcome was incident AF (I480-I482 and I489). Cox proportional hazards models were used to estimate hazard ratios of AF according to present insomnia (versus absent). RESULTS: Insomnia was observed in 216 919 individuals (12.2%), showing a significant association with incident AF after adjusting for potential confounding factors (adjusted hazard ratio, 1.14 [95% CI, 1.10-1.18]). Among subgroups, a similar pattern in the association between insomnia and incident AF was seen, while the association was stronger in younger individuals aged <65 years (versus >/=65 years) and women (versus men) (P for interaction=0.01 and 0.03, respectively). CONCLUSIONS: Insomnia was significantly associated with the risk of AF. It highlighted the importance of recognizing insomnia as a risk factor for AF, given its high prevalence in the general population and the substantial impact of AF on quality of life and prognosis. |
|---|
| ジャーナル名 | Journal of the American Heart Association |
|---|
| Pubmed追加日 | 2026/4/20 |
|---|
| 投稿者 | Masuda, Takuro; Ejiri, Kentaro; Kaneko, Hidehiro; Suzuki, Yuta; Miyoshi, Toru; Taya, Satoshi; Iwasaki, Keiichiro; Nakagawa, Koji; Nishii, Nobuhiro; Morita, Hiroshi; Okada, Akira; Fujiu, Katsuhito; Takeda, Norifumi; Morita, Hiroyuki; Yasunaga, Hideo; Takeda, Norihiko; Yuasa, Shinsuke |
|---|
| 組織名 | Department of Cardiovascular Medicine Okayama University Graduate School of;Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.;Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan.;Department of Advanced Cardiology The University of Tokyo Tokyo Japan.;Center for Outcomes Research and Economic Evaluation for Health, National;Institute of Public Health Saitama Japan.;Department of Cardiovascular Therapeutics Okayama University Graduate School of;Department of Prevention of Diabetes and Lifestyle-Related Diseases Graduate;School of Medicine, The University of Tokyo Tokyo Japan.;Department of Integrative Physiology Institute of Science Tokyo Tokyo Japan.;Department of Clinical Epidemiology and Health Economics, School of Public Health;The University of Tokyo Tokyo Japan. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42003621/ |
|---|
