| アブストラクト | BACKGROUND AND OBJECTIVE: Despite several case reports, population-based studies on interstitial lung disease (ILD) following COVID-19 vaccination are lacking. Given the unprecedented safety issue of COVID-19 vaccination, it is important to assess the worldwide patterns of ILD following COVID-19 vaccination. This study aimed to investigate the signals of COVID-19 vaccine-associated ILD compared with other vaccinations using disproportionality analysis. METHODS: We analysed the VigiBase database during the period between 13 December 2020 and 26 January 2023. We adopted the case/non-case approach to assess the disproportionality signal of ILD for COVID-19 vaccines via 1:10 matching by age and sex. We compared COVID-19 vaccines with all other vaccines as the reference group. RESULTS: Among 1 233 969 vaccine-related reports, 679 were reported for ILD. The majority of ILD cases were related to tozinameran (376 reports, 55.4%), Vaxzevria (129 reports, 19.0%) and elasomeran (78 reports, 11.5%). The reporting OR of ILD following COVID-19 vaccination was 0.86 (95% CI 0.64 to 1.15) compared with all other vaccines. CONCLUSION: No significant signal of disproportionate reporting of ILD was observed for COVID-19 vaccines compared with all other vaccines. Moreover, when compared with the influenza vaccines that are known to cause ILD, no signal was observed. This study results might help decision-making on the subsequent COVID-19 vaccination strategy of ILD. Further large and prospective studies are required for more conclusive evidence. |
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| ジャーナル名 | BMJ open respiratory research |
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| 投稿日 | 2023/12/12 |
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| 投稿者 | Lee, Min-Taek; Lee, Ju Won; Lee, Hyeon Ji; Lee, Jong-Min; Choi, Jae Chol; Gu, Kang-Mo; Jung, Sun-Young |
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| 組織名 | College of Pharmacy, Chung-Ang University, Seoul, Korea.;Department of Global Innovative Drugs, The Graduate School of Chung-Ang;University, Seoul, Korea.;Division of Pulmonary and Allergy Medicine, Department of Internal Medicine,;Chung-Ang University Gwangmyeong Hospital, Gwangmyeong-si, Gyeonggi-do, Korea.;Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul,;South Korea.;Chung-Ang University Hospital, Seoul, Korea.;College of Pharmacy, Chung-Ang University, Seoul, Korea jsyoung@cau.ac.kr. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38081769/ |
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