| アブストラクト | BACKGROUND: Drug-induced urinary retention (DIUR) can severely impact patient quality of life and complicate treatment. This study investigates the incidence and characteristics of DIUR using data from the FDA Adverse Event Reporting System (FAERS) over 20 years. METHODS: FAERS reports related to urinary retention (UR) from Q1 2004 to Q1 2024 were analyzed. Potential causative drugs were identified, and the top 30 drugs with the most UR reports were ranked. Statistical disproportionality analyses, including Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR), were conducted to detect significant safety signals. RESULTS: Out of 17,703,515 reports in the FAERS database 28,423 cases of UR were identified. Anticholinergics, antidepressants, and opioids were the most frequently implicated drug classes. The highest ROR and PRR values were observed for drugs like ezogabine. Additionally, less commonly associated drugs, such as adalimumab and others, were implicated, suggesting potential under-recognition of this adverse effect. However, these associations should be interpreted with caution, as they do not confirm a direct causal relationship. CONCLUSION: This study underscores the importance of pharmacovigilance in identifying and understanding DIUR. Further research is needed to confirm these findings and develop strategies to manage and reduce the risk, improving patient outcomes. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2024/9/14 |
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| 投稿者 | Zheng, Fuchun; Wang, Fei; Yuan, Yuyang; Wang, Zhipeng; Li, Sheng; Fu, Bin; Liu, Wei |
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| 組織名 | Department of Urology, The First Affiliated Hospital, Jiangxi Medical College,;Nanchang University, Nanchang, China.;Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China.;Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical;College, Nanchang University, Nanchang, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39275804/ |
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