| アブストラクト | PURPOSE: The rise in oesophageal adenocarcinoma incidence in women with age is delayed compared with men until the post-menopausal period. A matched cohort study was therefore undertaken of post-menopausal women on hormone replacement therapy (HRT) to examine the association between HRT, oesophageal cancer and the potentially associated conditions, reflux oesophagitis and Barrett's oesophagus. METHODS: Women aged over 50 years within the UK General Practice Research Database with a history of HRT exposure were matched by age and general practice with controls without HRT exposure (1:1). Matched Cox-regression analysis was performed to estimate adjusted hazard ratios. RESULTS: 51,851 HRT users and controls were studied. Prolonged HRT use for 5-10 years (hazard ratio 0.25 (95% CI 0.07-0.95)) and time-dependent covariates for increasing duration of HRT use (0.06 (0.01-0.43)) were associated with a reduced oesophageal cancer risk. HRT use was associated with reflux oesophagitis (1.27 (1.12-1.43)), but when analysis was confined to women with codes for both reflux oesophagitis and endoscopy there was no association (1.1 (0.81-1.44)), suggesting increased reporting of reflux symptoms among HRT users rather than an association with endoscopic reflux oesophagitis. CONCLUSION: Long-term post-menopausal HRT may be associated with a reduced risk of oesophageal cancer. |
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| ジャーナル名 | United European gastroenterology journal |
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| Pubmed追加日 | 2014/11/02 |
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| 投稿者 | Menon, Shyam; Nightingale, Peter; Trudgill, Nigel |
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| 組織名 | Royal Wolverhampton NHS Trust, Wolverhampton, UK.;Wolfson Computer Laboratories, Queen Elizabeth Hospital, Birmingham, UK.;Sandwell General Hospital, West Bromwich, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25360315/ |
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