| アブストラクト | BACKGROUND: Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database. METHODS: All spontaneous EV reports relating to loperamide misuse/abuse/dependence/withdrawal and cardiotoxicity issues were here retrieved, performing a descriptive analysis. FINDINGS: During the years 2005-2017, EV collected a number of 1,983 (out of a total of 7,895; 25.11%) loperamide-related misuse/abuse/dependence/withdrawal adverse drug reaction (ADR) reports, with a progressively increasing trend since 2014. Most cases were classified as drug use disorder (37.4%) or intentional overdose (25.4%). Loperamide was used on its own in 41.9% of cases; remaining, polydrug, cases included antidepressants; benzodiazepines; and other OTCs. Some 1,085 (1,085/7,895 = 13.7%) cardiovascular ADRs were reported, being conduction abnormalities and EKG alterations the most frequently identified. CONCLUSIONS: EV data may support the levels of concern relating to loperamide potential of abuse and associated cardiotoxicity issues. |
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| ジャーナル名 | PloS one |
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| 投稿日 | 2018/10/5 |
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| 投稿者 | Schifano, Fabrizio; Chiappini, Stefania |
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| 組織名 | Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit,;School of Life and Medical Sciences, University of Hertfordshire, Hatfield,;Herts, United Kingdom.;Casa di Cura Villa Rosa, Viterbo (VT), Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30286103/ |
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