| アブストラクト | BACKGROUND/AIM: Tranexamic acid (TXA) is widely used as a hemostatic agent and for various other indications, including dermatological and inflammatory conditions. However, its association with thromboembolism in the real-world setting remains unclear. In this study, we aimed to evaluate this association. PATIENTS AND METHODS: We collected data from the Japan Adverse Drug Event Report database from Q1 2004 to Q3 2020 and performed reporting odds ratio analyses and multivariate logistic regression analysis. RESULTS: Overall, 1,735,923 reports were analyzed. TXA was the suspected causal drug in 54 cases of venous thromboembolism (VTE) and 8 cases of arterial thromboembolism. A significant signal was detected for VTE (reporting odds ratio=6.61; 95% confidence interval=5.03-8.70) but not for arterial thromboembolism. VTE cases involving TXA were more frequently reported in women and individuals with a body mass index of >/=25 than in other groups. CONCLUSION: TXA may be associated with VTE. The findings highlight the importance of careful patient monitoring during TXA administration, particularly in high-risk populations such as women and individuals who are overweight. |
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| ジャーナル名 | In vivo (Athens, Greece) |
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| Pubmed追加日 | 2025/6/28 |
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| 投稿者 | Ishida, Natsuko; Shibata, Toshihiro; Suga, Yukio; Ishizaki, Junko |
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| 組織名 | Faculty of Pharmacy, Institute of Medical, Pharmaceutical & Health Science,;Kanazawa University, Kanazawa, Japan naishida@p.kanazawa-u.ac.jp.;Kanazawa University, Kanazawa, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40578992/ |
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