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Kawasaki disease and immunisation: A systematic review.

• アブストラクト	BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging. CONCLUSIONS: Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.
  ジャーナル名	Vaccine
  投稿日	2017/3/6
  投稿者	Phuong, Linny Kimly; Bonetto, Caterina; Buttery, Jim; Pernus, Yolanda Brauchli; Chandler, Rebecca; Felicetti, Patrizia; Goldenthal, Karen L; Kucuku, Merita; Monaco, Giuseppe; Pahud, Barbara; Shulman, Stanford T; Top, Karina A; Trotta, Francesco; Ulloa-Gutierrez, Rolando; Varricchio, Frederick; de Ferranti, Sarah; Newburger, Jane W; Dahdah, Nagib; Singh, Surjit; Bonhoeffer, Jan; Burgner, David
  組織名	Monash Children's Hospital, Clayton, Melbourne, Australia; Royal Children's;Hospital, Parkville, Victoria, Australia.;Italian Medicines Agency (AIFA), Rome, Italy.;Monash Children's Hospital, Clayton, Melbourne, Australia; Murdoch Childrens;Research Institute, Parkville, Victoria, Australia; Department of Paediatrics,;Monash University, Clayton, Victoria, Australia.;The Brighton Collaboration Foundation, Basel, Switzerland.;Uppsala Monitoring Centre, Uppsala, Sweden.;Independent Consultant, Bethesda, MD, USA.;Department of Vaccines Control, National Agency for Medicines and Medical;Devices, Tirana, Albania.;Pharmacovigilance Regional Centre of Lombardy, Italy.;Children's Mercy Hospital, Kansas City, MO, USA.;Ann & Robert H. Lurie Children's Hospital of Chicago, USA.;Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.;Hospital Nacional de Ninos "Dr. Carlos Saenz Herrera, San Jose, Costa Rica.;Independent Consultant Vaccinologist, Wakefield, RI, USA.;Boston Children's Hospital, Boston, USA.;CHU Sainte-Justine, Montreal, Canada.;Post Graduate Institute of Medical Education and Research (PGIMER)- Chandigarh,;India.;The Brighton Collaboration Foundation, Basel, Switzerland; University of Basel;Children's Hospital, Basel, Switzerland. Electronic address:;contact@brightoncollaboration.org.;Monash University, Clayton, Victoria, Australia; Department of Paediatrics,;Melbourne University, Parkville, Victoria, Australia.
  Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/28259442/

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