| アブストラクト | BACKGROUND AND AIMS: We aimed to evaluate the life expectancy following the first cardiovascular disease (CVD) event by type 2 diabetes (T2D) status and ethnicity. METHODS AND RESULTS: We used the Clinical Practice Research Datalink database in England (UK), linked to the Hospital Episode Statistics information, to identify individuals with and without T2D who survived a first CVD event between 1st Jan 2007 and 31st Dec 2017; subsequent death events were extracted from the Office for National Statistics database. Ethnicity was categorised as White, South Asian (SA), Black, or other. Flexible parametric survival models were used to estimate survival and predict life expectancy. 59,939 individuals with first CVD event were included: 7596 (12.7%) with T2D (60.9% men; mean age at event: 69.7 years [63.2 years in SA, 65.9 in Black, 70.2 in White]) and 52,343 without T2D (56.7% men; 65.9 years [54.7 in Black, 58.2 in SA, 66.3 in White]). Accounting for potential confounders (sex, deprivation, lipid-lowering medication, current smoking, and pre-existing hypertension), comparing individuals with vs without T2D the mortality rate was 53% higher in White (hazard ratio [HR]: 1.53 [95% CI: 1.44, 1.62]), corresponding to a potential loss of 3.87 (3.30, 4.44) life years at the age of 50 years in individuals with T2D. No evidence of a difference in life expectancy was observed in individuals of SA (HR: 0.82 [0.52, 1.29]; -1.36 [-4.58, 1.86] life years), Black (HR: 1.26 [0.59, 2.70]; 1.21 [-2.99, 5.41] life years); and other (HR: 1.64 [0.80, 3.39]; 3.89 [-2.28, 9.99] life years) ethnic group. CONCLUSION: Following a CVD event, T2D is associated with a different prognosis and life years lost among ethnic groups. |
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| ジャーナル名 | Nutrition, metabolism, and cardiovascular diseases : NMCD |
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| Pubmed追加日 | 2023/5/12 |
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| 投稿者 | Chudasama, Yogini V; Khunti, Kamlesh; Coles, Briana; Gillies, Clare L; Islam, Nazrul; Rowlands, Alex V; Seidu, Samuel; Razieh, Cameron; Davies, Melanie J; Samani, Nilesh J; Yates, Thomas; Zaccardi, Francesco |
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| 組織名 | Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General;Hospital, University of Leicester, Leicester, UK. Electronic address:;yc244@leicester.ac.uk.;kk22@leicester.ac.uk.;bc188@leicester.ac.uk.;clg13@leicester.ac.uk.;Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield;Department of Population Health, University of Oxford, Oxford, UK. Electronic;address: nazrul.islam@ndph.ox.ac.uk.;NIHR Leicester Biomedical Research Centre, Leicester Diabetes Centre, Leicester,;UK. Electronic address: alex.rowlands@leicester.ac.uk.;sis11@leicester.ac.uk.;UK; Office for National Statistics, Newport, NP10 8XG, UK. Electronic address:;cr288@leicester.ac.uk.;UK. Electronic address: melanie.davies@uhl-tr.nhs.uk.;Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research;Centre, University of Leicester, Leicester, UK. Electronic address:;njs@leicester.ac.uk.;UK. Electronic address: ty20@leicester.ac.uk.;fz43@leicester.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37169664/ |
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