| アブストラクト | AIMS: Few studies have investigated linezolid (LZD)-associated cardiotoxicity. This study explored the potential association between LZD and QT interval prolongation. METHODS: Adverse event reports of QT interval prolongation associated with LZD from the Food and Drug Administration Adverse Event Reporting System from January 2013 to December 2021 were analysed and the reporting odds ratio (ROR) with 95% confidence intervals were calculated. RESULTS: A total of 6738 adverse event reports of LZD as the primary and secondary suspected drug were obtained from the database, including 192 reports with electrocardiogram QT prolonged (QTp), and the ROR value was 26.1 (95% CI = 22.6-30.2). There were 8 reports of long QT syndrome, ROR 14.2 (95% CI = 7.1-28.5); 5 reports of torsade de pointes, ROR 3.2 (95% CI = 1.3-7.6); and 5 reports of ventricular tachycardia, ROR 1.9 (95% CI = 0.8-4.5). Subgroup analysis revealed that patients with tuberculosis treated with LZD had a higher reporting rate among all QTp reports, exhibiting an odds ratio of 330.0 (95% CI = 223.1-488.1). The odds ratios of QTp associated with LZD treatments in patients with and without tuberculosis were 4.2 (95% CI = 3.4-5.3) and 1.2 (95% CI = 0.8-1.6), respectively. CONCLUSION: The study showed an association between LZD and QT interval prolongation. In the report on patients with tuberculosis, the incidence of QTp was higher when treated with LZD. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| 投稿日 | 2022/11/9 |
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| 投稿者 | Shao, Haixia; Shi, Dawei; Dai, Ying |
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| 組織名 | Department of Pharmacy, Second Affiliated Hospital and Yuying Children's hospital;of Wenzhou Medical University, Wenzhou City, China.;Department of Pharmacy, First Affiliated Hospital of Wenzhou Medical University,;Wenzhou City, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36346345/ |
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