| アブストラクト | Loiasis, a filarial vector-borne disease, is common in rural West and Central Africa. Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. There is growing evidence that benzimidazoles might also lead to Loa loa-associated encephalopathy. In this systematic review we analyzed all available evidence of benzimidazole-associated encephalopathy. Literature was systematically searched in PubMed, Google Scholar, and WHO-VigiBase(R), including conference abstracts and consultation of experts. Six potential cases of benzimidazole-associated encephalopathy, including 2 fatalities, were identified among microfilaremic loiasis patients. Due to the limited global use of prolonged benzimidazole regimens for loiasis, the number of encephalopathy cases identified raises significant safety concerns, challenging the rationale of their use. Further research on mechanisms and safer alternative regimens is urgently needed. |
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| ジャーナル名 | Open forum infectious diseases |
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| Pubmed追加日 | 2025/12/11 |
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| 投稿者 | Davi, Saskia Dede; Nordmann, Tamara; Endamne, Lillian Rene; Ndzebe Ndoumba, Wilfrid; Adegnika, Ayola A; Agnandji, Selidji T; Lell, Bertrand; Kremsner, Peter Gottfried; Mombo-Ngoma, Ghyslain; Zoleko Manego, Rella; Ramharter, Michael |
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| 組織名 | Center for Tropical Medicine, Bernhard-Nocht Institute for Tropical Medicine & I.;Dept. of Medicine University Medical Center Hamburg-Eppendorf, Hamburg, Germany.;German Centre for Infection Research, Partner Site Hamburg-Lubeck-Borstel-Riems,;Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.;Centre de Recherches Medicales de Lambarene, Lambarene, Gabon Lambarene, Gabon.;Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany.;German Center for Infection Research, Partner Site Tubingen, Tubingen, Germany.;Department of Implementation Research, Bernhard-Nocht Institute for Tropical;Medicine, Hamburg, Germany. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41377593/ |
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