| アブストラクト | AIMS: Studies using contemporary cohorts are needed to assess the association between type 2 diabetes and cancer. METHODS: Using the United Kingdom Clinical Practice Research Datalink, we matched patients with type 2 diabetes between 1988 and 2019 to patients without type 2 diabetes. Poisson regression models were fit to estimate incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for cancer. In secondary analyses, we determined whether the strength of the association varied with calendar time and whether patients with type 2 diabetes had a higher incidence of being diagnosed with multiple cancers during the follow-up period. RESULTS: 890,214 patients with type 2 diabetes were matched to an equal number of patients without type 2 diabetes. Patients with type 2 diabetes had a higher cancer incidence than patients without type 2 diabetes (IRR 1.19, 95% CI 1.18-1.21). The IRR was higher 2010 onwards (IRR: 1.25, 95% CI: 1.23-1.28) compared with the association in previous years. Overall, patients with type 2 diabetes had a 5% higher incidence of being diagnosed with multiple cancers (IRR: 1.05, 95% CI: 1.04-1.07). CONCLUSIONS: The results of this large population-based study indicate that type 2 diabetes is associated with an increased risk of several cancers. |
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| 組織名 | Department of Epidemiology, Biostatistics, and Occupational Health, McGill;University, Montreal, Canada; Center for Clinical Epidemiology, Lady Davis;Institute, Jewish General Hospital, Montreal, Canada.;Division of Endocrinology, Jewish General Hospital, Montreal, Canada.;Institute, Jewish General Hospital, Montreal, Canada; Gerald Bronfman Department;of Oncology, McGill University, Montreal, Canada. Electronic address:;laurent.azoulay@mcgill.ca. |
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