| アブストラクト | BACKGROUND: A possible association between low-molecular-weight heparins (LMWHs) and thrombocytosis was suspected from spontaneous reports to the French Pharmacovigilance System. This association is not mentioned in LMWH's summary of product characteristics. METHODS: All case records in the French Pharmacovigilance database were reanalyzed for relevance and causality, and the case/noncase approach was used including reports of thrombocytosis as cases and all other reports as noncases. RESULTS: Fifty-one patients treated with LMWHs had platelet counts >500 x 10(3)/mm(3). All patients were asymptomatic, and 1 had a positive rechallenge. There were 143 cases of thrombocytosis among the 174 213 reports in the database, with 61 of 4644 involving LMWHs. The calculated relative reporting ratio is 27.5 (p < 0.0001; 95% CI 19.5 to 38.9). CONCLUSIONS: There is a highly significant association of thrombocytosis reported with LMWH treatment. |
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| ジャーナル名 | The Annals of pharmacotherapy |
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| 投稿日 | 2002/8/28 |
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| 投稿者 | Liautard, Christine; Nunes, Ana-Maria Correa; Vial, Thierry; Chatillon, Fabienne; Guy, Claire; Ollagnier, Michel; Descotes, Jacques |
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| 組織名 | Centre Antipoison, Centre de Pharmacovigilance, Hopital Edouard Herriot, Lyon,;France. jacques.descotes@chu-lyon.fr |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/12196050/ |
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