| アブストラクト | Objective: Immune checkpoint inhibitors, such as programmed death-1/ligand-1 (PD-1/L1), exhibited autoimmune-like disorders, and hyperglycemia was on the top of grade 3 or higher immune-related adverse events. Machine learning is a model from past data for future data prediction. From post-marketing monitoring, we aimed to construct a machine learning algorithm to efficiently and rapidly predict hyperglycemic adverse reaction in patients using PD-1/L1 inhibitors. Methods: In original data downloaded from Food and Drug Administration Adverse Event Reporting System (US FAERS), a multivariate pattern classification of support vector machine (SVM) was used to construct a classifier to separate adverse hyperglycemic reaction patients. With correct core SVM function, a 10-fold 3-time cross validation optimized parameter value composition in model setup with R language software. Results: The SVM prediction model was set up from the number type/number optimization method, as well as the kernel and type of "rbf" and "nu-regression" composition. Two key values (nu and gamma) and case number displayed high adjusted r (2) in curve regressions (nu = 0.5649 x e ((- (case/6984))), gamma = 9.005 x 10(-4) x case - 4.877 x 10(-8) x case(2)). This SVM model with computable parameters greatly improved the assessing indexes (accuracy, F1 score, and kappa) as well as coequal sensitivity and the area under the curve (AUC). Conclusion: We constructed an effective machine learning model based on compositions of exact kernels and computable parameters; the SVM prediction model can noninvasively and precisely predict hyperglycemic adverse drug reaction (ADR) in patients treated with PD-1/L1 inhibitors, which could greatly help clinical practitioners to identify high-risk patients and perform preventive measurements in time. Besides, this model setup process provided an analytic conception for promotion to other ADR prediction, such ADR information is vital for outcome improvement by identifying high-risk patients, and this machine learning algorithm can eventually add value to clinical decision making. |
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| ジャーナル名 | Journal of healthcare engineering |
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| 投稿日 | 2022/8/30 |
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| 投稿者 | Yang, Jincheng; Li, Ning; Lin, Weilong; Shi, Liming; Deng, Ming; Tong, Qin; Yang, Wenjing |
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| 組織名 | Office for Cancer Diagnosis and Treatment Quality Control, National Cancer;Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese;Academy of Medical Sciences and Peking Union Medical College, Beijing, China.;Department of Comprehensive Oncology, National Cancer Center, National Clinical;Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences;and Peking Union Medical College, Beijing, China.;Department of Acupuncture and Moxibustion, Wuhan Xinzhou District Hospital of;Traditional Chinese Medicine, Wuhan, Hubei, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36032541/ |
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