| アブストラクト | BACKGROUND: People with multiple sclerosis (pwMS) have an increased risk of infections; risk factors include underlying disease, physical impairment and use of some disease-modifying treatments. OBJECTIVE: To quantify changes in population-level infection rates among pwMS and compare these to the general population and people with rheumatoid arthritis (pwRA), and identify patient characteristics predictive of infections after MS diagnosis. METHODS: We conducted a multi-database study using data on 23,226 people with MS diagnosis from the UK Clinical Practice Research Datalink Aurum and GOLD (January 2000-December 2020). PwMS were matched to MS-free controls and pwRA. We calculated infection rates, and estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) of predictors for infections ⩽ 5 years after MS diagnosis using Poisson regression. RESULTS: Among pwMS, overall infection rates remained stable - 1.51-fold (1.49-1.52) that in MS-free controls and 0.87-fold (0.86-0.88) that in pwRA - although urinary tract infection rate per 1000 person-years increased from 98.7 (96.1-101) (2000-2010) to 136 (134-138) (2011-2020). Recent infection before MS diagnosis was most predictive of infections (1 infection: IRR 1.92 (1.86-1.97); ⩾2 infections: IRR 3.00 (2.89-3.10)). CONCLUSION: The population-level elevated risk of infection among pwMS has remained stable despite the introduction of disease-modifying treatments. |
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| ジャーナル名 | Multiple sclerosis (Houndmills, Basingstoke, England) |
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| Pubmed追加日 | 2022/5/17 |
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| 投稿者 | Leung, Melissa Wy; Bazelier, Marloes T; Souverein, Patrick C; Uitdehaag, Bernard Mj; Klungel, Olaf H; Leufkens, Hubert Gm; Pajouheshnia, Romin |
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| 組織名 | Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for;Pharmaceutical Sciences (UIPS), Department of Pharmaceutical Sciences, Faculty of;Science, Utrecht University, Utrecht, The Netherlands.;Department of Neurology, Amsterdam Neuroscience, VUmc MS Center Amsterdam, VU;University Medical Center, Amsterdam, The Netherlands. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35575214/ |
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