| アブストラクト | OBJECTIVE: Assessment of whether maternal anaemia in early pregnancy is associated with offspring congenital heart disease (CHD). DESIGN: Matched case-control study. SETTING: January 1998-October 2020, United Kingdom. POPULATION: Women with a haemoglobin measurement in the first 100 days of pregnancy and a CHD-diagnosed child. METHODS: Data were extracted from the United Kingdom Clinical Practice Research Datalink GOLD database of electronic health records. Cases were 2,776 women with a CHD-diagnosed child. These were compared to 13 880 matched controls, women without a CHD-diagnosed child. Anaemia was classified as < 110 g/L haemoglobin following the WHO definition. A conditional logistic regression analysis was conducted, adjusted for potential maternal demographic and health-related confounders. MAIN OUTCOME MEASURES: Offspring CHD diagnosed within 5 years of birth. RESULTS: 123 (4.4%) cases and 390 (2.8%) controls had anaemia. After adjusting for potential confounders, the odds of giving birth to a CHD-diagnosed child were 47% higher among anaemic mothers (adjusted OR 1.47, 95% CI 1.18,1.83, p < 0.001). CONCLUSIONS: The observed association between maternal anaemia in early pregnancy and increased risk of offspring CHD supports our recent evidence in mice. Approximately two-thirds of anaemia cases globally are due to iron deficiency. A clinical trial of periconceptional iron supplementation might be a minimally invasive and low-cost intervention for the prevention of some CHD if iron deficiency anaemia is proven to be a cause. |
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| ジャーナル名 | BJOG : an international journal of obstetrics and gynaecology |
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| Pubmed追加日 | 2025/4/23 |
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| 投稿者 | Nair, Manisha; Drakesmith, Cynthia W; Smith, Margaret; Bankhead, Clare R; Sparrow, Duncan B |
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| 組織名 | National Perinatal Epidemiology Unit, Nuffield Department of Population Health,;University of Oxford, Oxford, UK.;Nuffield Department of Primary Care Health Sciences, University of Oxford,;Oxford, UK.;Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40264354/ |
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