| アブストラクト | INTRODUCTION: One in five pregnant women has multiple pre-existing long-term conditions in the UK. Studies have shown that maternal multiple long-term conditions are associated with adverse outcomes. This observational study aims to compare maternal and child outcomes for pregnant women with multiple long-term conditions to those without multiple long-term conditions (0 or 1 long-term conditions). METHODS AND ANALYSIS: Pregnant women aged 15-49 years old with a conception date between 2000 and 2019 in the UK will be included with follow-up till 2019. The data source will be routine health records from all four UK nations (Clinical Practice Research Datalink (England), Secure Anonymised Information Linkage (Wales), Scotland routine health records and Northern Ireland Maternity System) and the Born in Bradford birth cohort. The exposure of two or more pre-existing, long-term physical or mental health conditions will be defined from a list of health conditions predetermined by women and clinicians. The association of maternal multiple long-term conditions with (a) antenatal, (b) peripartum, (c) postnatal and long-term and (d) mental health outcomes, for both women and their children will be examined. Outcomes of interest will be guided by a core outcome set. Comparisons will be made between pregnant women with and without multiple long-term conditions using modified Poisson and Cox regression. Generalised estimating equation will account for the clustering effect of women who had more than one pregnancy episode. Where appropriate, multiple imputation with chained equation will be used for missing data. Federated analysis will be conducted for each dataset and results will be pooled using random-effects meta-analyses. ETHICS AND DISSEMINATION: Approval has been obtained from the respective data sources in each UK nation. Study findings will be submitted for publications in peer-reviewed journals and presented at key conferences. |
|---|
| 投稿者 | Lee, Siang Ing; Hope, Holly; O'Reilly, Dermot; Kent, Lisa; Santorelli, Gillian; Subramanian, Anuradhaa; Moss, Ngawai; Azcoaga-Lorenzo, Amaya; Fagbamigbe, Adeniyi Francis; Nelson-Piercy, Catherine; Yau, Christopher; McCowan, Colin; Kennedy, Jonathan Ian; Phillips, Katherine; Singh, Megha; Mhereeg, Mohamed; Cockburn, Neil; Brocklehurst, Peter; Plachcinski, Rachel; Riley, Richard D; Thangaratinam, Shakila; Brophy, Sinead; Hemali Sudasinghe, Sudasing Pathirannehelage Buddhika; Agrawal, Utkarsh; Vowles, Zoe; Abel, Kathryn Mary; Nirantharakumar, Krishnarajah; Black, Mairead; Eastwood, Kelly-Ann |
|---|
| 組織名 | Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;Centre for Women's Mental Health, Faculty of Biology Medicine & Health, The;University of Manchester, Manchester, UK.;Centre for Public Health, Queen's University Belfast, Belfast, UK.;Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust,;Bradford, UK.;Patient and Public Representative, London, UK.;Division of Population and Behavioural Sciences, University of St Andrews School;of Medicine, St Andrews, UK.;Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Hospital Rey Juan;Carlos, Mostoles, Spain.;Department of Epidemiology and Medical Statistics, University of Ibadan College;of Medicine, Ibadan, Nigeria.;Guy's and St Thomas' NHS Foundation Trust, London, UK.;Nuffield Department of Women's and Reproductive Health, University of Oxford,;Oxford, UK.;Health Data Research UK, London, UK.;Data Science, Medical School, Swansea University, Swansea, UK.;WHO Collaborating Centre for Global Women's Health, University of Birmingham;Institute of Metabolism and Systems Research, Birmingham, UK.;Department of Obstetrics and Gynaecology, Birmingham Women's and Children's NHS;Foundation Trust, Birmingham, UK.;Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK.;Institute of Applied Health Research, University of Birmingham, Birmingham, UK;k.nirantharan@bham.ac.uk.;Aberdeen Centre for Women's Health Research, University of Aberdeen School of;Medicine Medical Sciences and Nutrition, Aberdeen, UK.;University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK. |
|---|
