| アブストラクト | Vaccination against coronavirus is essential to minimize COVID-19 pandemic. Rare cases of anaphylaxis associated with the mRNA COVID-19 vaccines are being described, and the mechanisms involved in these reactions are poorly understood. A potential culprit agent of these vaccine-induced anaphylaxis is the polyethylene glycol, which has been reported as a cause of anaphylaxis. However, a cause-effect association has not been demonstrated and the cases of anaphylaxis to mRNA COVID-19 vaccines should be further investigated. In this scenario, the recommendations are inaccurate and can lead to misinterpretation. At the moment, a more accurate recommendation would be the contraindication of mRNA COVID-19 vaccines in patients with immediate hypersensitivity reaction to polyethylene glycol or polysorbate. Patients with history of anaphylaxis to other or unknown causes should be referral to an allergist-immunologist to further orientation. |
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| 投稿日 | 2021/3/23 |
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| 投稿者 | Giavina-Bianchi, Pedro; Kalil, Jorge |
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| ジャーナル名 | The World Allergy Organization journal |
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| 組織名 | Clinical Immunology and Allergy Division, Faculdade de Medicina da Universidade;de Sao Paulo, Sao Paulo, Brazil. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33747340/ |
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