| アブストラクト | INTRODUCTION: Infection-related adverse events are an important safety concern in psoriasis therapy. OBJECTIVE: To compare infection-related adverse-event reporting across mechanism-based therapy groups. METHODS: We analyzed psoriasis-indicated US Food and Drug Administration Adverse Event Reporting System (FAERS) reports from 2014 Q3 through 2025 Q3. Sixteen therapies were grouped as TNF, IL-12/23, IL-17, and IL-23 inhibitors and immunosuppressive or non-immunosuppressive nonbiologics. Primary exposure was a primary- or secondary-suspect listing; sensitivity analysis required drug-sequence linkage to psoriatic disease. Reporting odds ratios (RORs) and information-component lower bounds (IC(025)) were calculated. RESULTS: Among 357,728 reports, 67,827 contained an infection term. Signals were strongest for immunosuppressive nonbiologics (ROR 2.51; IC(025) 0.88) and IL-12/23 inhibition (2.43; 0.83), followed by IL-17 inhibitors (1.82; 0.47). TNF inhibitors showed a modest signal (1.17; 0.11), whereas IL-23 inhibitors were near null (0.99; -0.04). Indication linkage attenuated the immunosuppressive-nonbiologic signal to ROR 1.14 (IC(025) 0.09), while IL-12/23 and IL-17 signals persisted. IL-17 inhibitors showed a Candida signal (ROR 8.67; IC(025) 1.55). CONCLUSION: Reporting estimates varied by mechanism, and exposure attribution materially influenced the immunosuppressive-nonbiologic result. |
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| ジャーナル名 | The Journal of dermatological treatment |
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| Pubmed追加日 | 2026/9/29 |
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| 投稿者 | Hwang, Shinwon; Kwak, Yerim; Jung, Yeon Woo; Jung, Se Yong; Shin, Jae Il; Kim, Tae-Gyun |
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| 組織名 | Department of Dermatology, Cutaneous Biology Research Institute, Yonsei;University College of Medicine, Seoul, South Korea.;Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.;Department of Pediatrics, Yonsei University College of Medicine, Seoul, South;Korea.;Severance Underwood Meta-Research Center, Institute of Convergence Science,;Yonsei University, Seoul, South Korea.;Department of Dermatology, Severance Hospital, Cutaneous Biology Research;Institute, Institute for Immunology and Immunological Diseases, Yonsei University;College of Medicine, Seoul, South Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42806931/ |
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