| アブストラクト | OBJECTIVE: Different classes of medication have been reported in the literature to be associated with an increased risk of gastrointestinal perforation. However, little is known about the risk of drug-induced perforated appendicitis. METHODS: We analyzed the Food and Drug Administration Adverse Event Reporting System (FAERS), a large national database of reported adverse events associated with post-market FDA-approved medications from January 2011 to October 2021. Patients of any age group with appendiceal perforation were included. Duplicated reports and other anatomical areas of gastrointestinal tract perforation outside the appendix were excluded. RESULTS: During the study period, 474 event cases met inclusion criteria, of which 284 were females. Most reports of perforation occurred in patients 40-49 years (n = 110) and 50-59 years (n = 144). Cases of perforated appendicitis occurred in patients being treated for multiple sclerosis (31.5%) and rheumatoid arthritis (17.1%). Perforation occurred in patients receiving interferon beta 1a (23.6%), adalimumab (17.9%), etanercept (14.1%), natalizumab (12.2%), clozapine (10.1%), infliximab (9.9%), bevacizumab (7.2%), and calcium chloride (4.9%). Sixteen fatal outcomes were reported. CONCLUSION: Findings from the FAERS database highlight the risk of appendiceal perforation in the context of different classes of drugs. Larger pharmacovigilance studies are needed to confirm these observations. |
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| ジャーナル名 | Expert review of gastroenterology & hepatology |
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| 投稿日 | 2022/11/3 |
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| 投稿者 | Ramai, Daryl; Mozell, Daniel; Facciorusso, Antonio; Kewalramani, Anjali; Chandan, Saurabh; Dhindsa, Banreet; Dhaliwal, Amaninder; Khan, Shahab; Adler, Douglas G |
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| 組織名 | Division of Gastroenterology and Hepatology, University of Utah Health, Salt Lake;City.;Department of Medicine, the Brooklyn Hospital Center, Brooklyn.;Section of Gastroenterology, Department of Medical Sciences, University of;Foggia, 71122 Foggia, Italy.;Mather Hospital, Port Jefferson, New York, United States.;Division of Gastroenterology & Hepatology, CHI Health Creighton University;Medical Center, Omaha.;Gastroenterology & Hepatology, University of Nebraska Medical Center, Omaha.;Division of Gastroenterology, McLeod Health Center, Florence, South Carolina,;USA.;Department of Medicine, Brigham and Women's Hospital- Harvard Medical School,;Boston, Massachusetts, USA.;Center for Advanced Therapeutic Endoscopy (CATE), Porter Adventist Hospital/PEAK;Gastroenterology, Denver. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36322707/ |
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