| アブストラクト | A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most priapism-reports; and, b) within these medications, comparing their potential to elicit priapism through a disproportionality analysis. The FDA Adverse Event Reporting System (FAERS) database was queried to identify those drugs associated the most with priapism reports over the last 5 years. Only those drugs being associated with a minimum of 30 priapism reports were considered. The Proportional Reporting Ratios (PRRs), and their 95% confidence intervals were computed. Out of the whole 2015-2020 database, 1233 priapism reports were identified, 933 of which (75.7%) were associated with 11 medications with a minimum of 30 priapism-reports each. Trazodone, olanzapine and tadalafil showed levels of disproportionate reporting, with a PRR of 9.04 (CI95%: 7.73-10.58), 1.55 (CI95%: 1.27-1.89), and 1.42 (CI95%: 1.10-1.43), respectively. Most (57.5%) of the reports associated with the phosphodiesterase type 5 inhibitors (PDE5Is) were related with concomitant priapism-eliciting drugs taken at the same time and/or inappropriate intake/excessive dosage. Patients taking trazodone and/or antipsychotics need to be aware of the priapism-risk; awareness among prescribers would help in reducing priapism-related detrimental sequelae; PDE5I-intake is not responsible for priapism by itself, when appropriate medical supervision is provided. |
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| ジャーナル名 | International journal of impotence research |
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| 投稿日 | 2022/5/22 |
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| 投稿者 | Schifano, Nicolo; Capogrosso, Paolo; Boeri, Luca; Fallara, Giuseppe; Cakir, Omer Onur; Castiglione, Fabio; Alnajjar, Hussain M; Muneer, Asif; Deho', Federico; Schifano, Fabrizio; Montorsi, Francesco; Salonia, Andrea |
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| 組織名 | Universita Vita-Salute San Raffaele, Milan, Italy.;Division of Experimental Oncology/Unit of Urology, URI; IRCCS Ospedale San;Raffaele, Milan, Italy.;ASST Sette Laghi-Circolo e Fondazione Macchi Hospital, Varese, Italy.;Department of Urology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico,;University of Milan, Milan, Italy.;Institute of Andrology, Department of Urology, University College London;Hospitals NHS Trust, London, UK.;Division of Surgery and Interventional Science, UCL, London, UK.;Psychopharmacology; Drug Misuse; and Novel Psychoactive Substances Research Unit,;School of Life and Medical Sciences, University of Hertfordshire, Hatfield,;Herts, UK.;Universita Vita-Salute San Raffaele, Milan, Italy. salonia.andrea@hsr.it.;Raffaele, Milan, Italy. salonia.andrea@hsr.it. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35597798/ |
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