| アブストラクト | SUMMARY: MetaADEDB is an online database we developed to integrate comprehensive information on adverse drug events (ADEs). The first version of MetaADEDB was released in 2013 and has been widely used by researchers. However, it has not been updated for more than seven years. Here, we reported its second version by collecting more and newer data from the U.S. FDA Adverse Event Reporting System (FAERS) and Canada Vigilance Adverse Reaction Online Database, in addition to the original three sources. The new version consists of 744 709 drug-ADE associations between 8498 drugs and 13 193 ADEs, which has an over 40% increase in drug-ADE associations compared to the previous version. Meanwhile, we developed a new and user-friendly web interface for data search and analysis. We hope that MetaADEDB 2.0 could provide a useful tool for drug safety assessment and related studies in drug discovery and development. AVAILABILITY AND IMPLEMENTATION: The database is freely available at: http: //lmmd.ecust.edu.cn/metaadedb/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. |
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| 投稿日 | 2020/12/12 |
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| 投稿者 | Yu, Zhuohang; Wu, Zengrui; Li, Weihua; Liu, Guixia; Tang, Yun |
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| ジャーナル名 | Bioinformatics (Oxford, England) |
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| 組織名 | Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China;University of Science and Technology, Shanghai 200237, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33306787/ |
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