| アブストラクト | AIM: To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population. METHOD: A cohort study was conducted using data from adults with CP in England, identified through a primary care data set (the Clinical Practice Research Datalink), with linked data on death registrations from the Office for National Statistics. Cause of death was categorized according to International Classification of Diseases codes. Standardized mortality ratios (SMRs) were calculated to compare mortality rates between adults with CP and the general population, adjusted for age, sex, and calendar year. RESULTS: Nine hundred and fifty-eight adults with CP were identified (52.5% males, 47.5% females; median age at start of follow-up 31y [interquartile range 22-43y]) and followed for a total of 7693 person-years. One hundred and forty-two patients (15%) died during follow-up. Adults with CP had an increased risk of death due to cardiovascular disease (SMR: 3.19, 95% confidence interval [CI] 2.20-4.62) and respiratory disease (SMR: 13.59, 95% CI 9.89-18.67), but not from malignant neoplasms (SMR: 1.42, 95% CI 0.83-2.45). INTERPRETATION: We found that adults with CP in England have increased risk of death due to diseases of the circulatory and respiratory systems, supporting findings from two studies that compared cause-specific mortality rates between adults with CP in the USA and the general population. Further research is required into primary and secondary prevention of cardiovascular and respiratory disease in people with CP worldwide. WHAT THIS PAPER ADDS: Adults with cerebral palsy (CP) in England have 14-fold increased risk of mortality due to diseases of the respiratory system. They have a 3-fold increased risk of mortality due to diseases of the circulatory system. Adults with CP had an increased risk of death due to cerebrovascular disease and ischaemic heart disease. The elevated risk of ischaemic heart disease, however, did not reach statistical significance at the 5% per cent level. |
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| ジャーナル名 | Developmental medicine and child neurology |
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| 投稿日 | 2019/2/7 |
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| 投稿者 | Ryan, Jennifer M; Peterson, Mark D; Ryan, Nicola; Smith, Kimberley J; O'connell, Neil E; Liverani, Silvia; Anokye, Nana; Victor, Christina; Allen, Elizabeth |
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| 組織名 | Department of Epidemiology and Public Health Medicine, Royal College of Surgeons;in Ireland, Dublin, Ireland.;Institute of Environment, Health and Societies, Brunel University London, London,;UK.;Department of Physical Medicine and Rehabilitation, University of Michigan;Medicine, Ann Arbor, MI, USA.;Department of Cardiology, Aberdeen Royal Infirmary, Aberdeen, UK.;Department of Interventional Cardiology, Hospital Clinico San Carlos, Madrid,;Spain.;Department of Psychological Sciences, Faculty of Health and Medical Sciences,;University of Surrey, Guildford, UK.;School of Mathematical Sciences, Queen Mary University of London, London, UK.;Department of Medical Statistics, London School of Hygiene and Tropical Medicine,;London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/30727025/ |
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