| アブストラクト | OBJECTIVE: This study aimed to estimate and compare mortality of care home residents, and matched community-dwelling controls, during the COVID-19 pandemic from primary care electronic health records in England. DESIGN: Matched cohort study. SETTING AND PARTICIPANTS: Family practices in England in the Clinical Practice Research Datalink Aurum database. There were 83,627 care home residents in 2020, with 26,923 deaths; 80,730 (97%) were matched on age, sex, and family practice with 300,445 community-dwelling adults. METHODS: All-cause mortality was evaluated and adjusted rate ratios by negative binomial regression were adjusted for age, sex, number of long-term conditions, frailty category, region, calendar month or week, and clustering by family practice. RESULTS: Underlying mortality of care home residents was higher than community controls (adjusted rate ratio 5.59, 95% confidence interval 5.235.99, P < .001). During April 2020, there was a net increase in mortality of care home residents over that of controls. The mortality rate of care home residents was 27.2 deaths per 1000 patients per week, compared with 2.31 per 1000 for controls. Excess deaths for care home residents, above that predicted from pre-pandemic years, peaked between April 13 and 19 (men, 27.7, 95% confidence interval 25.130.3; women, 17.4, 15.918.8 per 1000 per week). Compared with care home residents, long-term conditions and frailty were differentially associated with greater mortality in community-dwelling controls. CONCLUSIONS AND IMPLICATIONS: Individual-patient data from primary care electronic health records may be used to estimate mortality in care home residents. Mortality is substantially higher than for community-dwelling comparators and showed a disproportionate increase in the first wave of the COVID-19 pandemic. Care home residents require particular protection during periods of high infectious disease transmission. |
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| ジャーナル名 | Journal of the American Medical Directors Association |
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| Pubmed追加日 | 2022/5/14 |
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| 投稿者 | Gulliford, Martin C; Prevost, A Toby; Clegg, Andrew; Rezel-Potts, Emma |
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| 組織名 | School of Population and Life Course Sciences, King's College London, Guy's;Campus, London, United Kingdom; NIHR Biomedical Research Centre at Guy's and St;Thomas' Hospitals London, Great Maze Pond, London, United Kingdom. Electronic;address: martin.gulliford@kcl.ac.uk.;Nightingale-Saunders Clinical Trials and Epidemiology Unit, Cicely Saunders;Institute, King's College London, London, United Kingdom.;Bradford Institute for Health Research, Bradford Teaching Hospitals NHS;Foundation Trust, Bradford, United Kingdom; Academic Unit for Ageing and Stroke;Research, University of Leeds, Leeds, United Kingdom.;Thomas' Hospitals London, Great Maze Pond, London, United Kingdom. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35561757/ |
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