| アブストラクト | OBJECTIVES: Many rheumatological conditions have increased mortality rates; however, there is conflicting evidence regarding the impact of juvenile idiopathic arthritis (JIA) on mortality. This analysis aimed to calculate the all-cause mortality rate of patients with JIA, compared with (a) matched-control patients and (b) the general population mortality estimates. METHODS: Using the UK General Practice data Clinical Practice Research Datalink, JIA cases starting <16 years old from England were included, matched 4-to-1 with non-JIA controls (birth year, gender, practice). Exposure started on first JIA-code date (matched-date for controls) or January 1, 2000, whichever was latest. Follow-up continued until December 31, 2018, or death, whichever was first. Cox-proportional hazards models compared mortality in JIA versus matched controls. JIA rates were stratified by systemic versus non-systemic JIA. Standardised mortality rates (SMRs) were generated for JIA versus general population estimates (calendar year, age, gender). RESULTS: There were 4762 patients with JIA (30 deaths) and 13 957 matched controls (27 deaths); patient demographics were similar between cohorts. Mortality rate for JIA was 6.2/10 000 person years (95% CI: 4.3-8.9), and 1.9/10 000 person years (95% CI: 1.3-2.8) for matched controls; JIA patients had 3.3 times higher mortality (95% CI: 2.0-5.5). Patients with systemic JIA had 3.3 times higher mortality (95% CI: 1.6-6.9) versus those with non-systemic JIA. The SMR for JIA was 2.9 (95% CI: 2.1-4.2). Eighteen (60%) JIA deaths occurred before 2012. CONCLUSIONS: This analysis calculated mortality rates in young people with JIA in England. Death in young people with JIA is exceedingly rare. Higher rates were observed in patients with systemic JIA. Over half the deaths occurred prior to 2012 when biologic treatment, particularly for systemic JIA, was limited. |
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| ジャーナル名 | EULAR rheumatology open |
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| Pubmed追加日 | 2025/5/14 |
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| 投稿者 | Kearsley-Fleet, Lianne; Shaw, Natasha; Leslie, Jasmine; Johnson, Michelle; Wedderburn, Lucy R; Hyrich, Kimme L; Humphreys, Jenny H |
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| 組織名 | Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research,;Division of Musculoskeletal and Dermatological Sciences, University of;Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.;Infection, Immunity and Inflammation Research and Teaching Department, University;College London (UCL) Great Ormond Street Institute of Child Health, London, UK.;National Institute for Health and Care Research (NIHR) Biomedical Research Centre;at Great Ormond Street Hospital, London, UK.;Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospital and;Great Ormond Street Hospital, London, UK.;NIHR Manchester Biomedical Research Centre, Manchester University Hospitals;National Health Service (NHS) Trust, Manchester, UK.;Kellgren Centre for Rheumatology, Manchester Royal Infirmary, Manchester;University Hospitals NHS Trust, Manchester, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42368387/ |
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