| アブストラクト | BACKGROUND: Glycogen synthase kinase 3 beta (GSK-3beta) inhibitors have received substantial attention for their therapeutic potential; however, their systemic safety profile remains incompletely characterized. OBJECTIVE: This study characterized the research landscape and exploratory safety-reporting signals associated with agents with reported GSK-3beta activity by integrating bibliometric analysis, pharmacovigilance, and preliminary experimental assessment. METHODS: A multi-layered framework included bibliometric analysis, disproportionality analyses of FAERS, JADER, and CVARD reports, and transcriptomic profiling. SH-SY5Y cells were treated with 9-ING-41 (1 muM, 24 h); cell viability, qRT-PCR, and DCFH-DA-based intracellular oxidative-stress measurements were assessed. RESULTS: Bibliometric analysis showed sustained growth in GSK-3beta-related research. Pharmacovigilance identified neurological and hematologic disproportionality signals across 27 System Organ Classes. In SH-SY5Y cells, 9-ING-41 was associated with modest changes in neuronal-function, inflammatory-response, and GSK-3beta/Wnt-pathway transcripts, increased DCFH-DA fluorescence, and high cell viability. These cell-based observations are preliminary and do not establish clinical causality. CONCLUSION: The literature-derived study-drug panel showed exploratory neurological and hematologic reporting signals. Cross-database recurrence can prioritize hypotheses, whereas pharmacological heterogeneity and the limitations of spontaneous reporting require cautious interpretation. The SH-SY5Y experiments provide preliminary biological plausibility only. |
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| ジャーナル名 | Frontiers in immunology |
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| Pubmed追加日 | 2026/10/2 |
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| 投稿者 | Luan, Xinchi; Fan, Bingcheng; Wang, Xuezhe; Li, Xiaoxuan; Song, Yuhui; Zhang, Xiaolei; Zhang, Huhu; Chen, Ruolan; Li, Yi; Yang, Zelin; Liu, Ning; Qi, Weiwei; Qiu, Wensheng; Guo, Jing |
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| 組織名 | Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao,;Shandong, China.;Department of Cardiology, The Affiliated Hospital of Qingdao University,;Qingdao, China.;Massachusetts General Hospital Cancer Center, Boston, MA, United States.;Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao;University, Qingdao, China.;Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42824466/ |
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