| アブストラクト | OBJECTIVE: To compare the incidence of noncommunicable diseases between adults with and without cerebral palsy (CP). METHODS: A cohort study was conducted using primary care data from the Clinical Practice Research Datalink. Cox models, stratified by matched set and adjusted for potential confounders, were fitted to compare the risk of any noncommunicable disease, cancer, cardiovascular disease, type 2 diabetes mellitus, and respiratory disease between adults with and without CP. RESULTS: The analysis included 1,705 adults with CP and 5,115 age-, sex-, and general practice-matched adults without CP. There was evidence from adjusted analyses that adults with CP had 75% increased risk of developing any noncommunicable disease compared to adults without CP (hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.58-1.94). Specifically, they had increased risk of cardiovascular disease (HR 1.76, 95% CI 1.48-2.11) and respiratory disease (HR 2.61, 95% CI 2.14-3.19). There was no evidence of increased risk of cancer or type 2 diabetes mellitus. CONCLUSIONS: Adults with CP had increased risk of noncommunicable disease, specifically cardiovascular and respiratory disease. These findings highlight the need for clinical vigilance regarding identification of noncommunicable disease in people with CP and further research into the etiology and management of noncommunicable disease in this population. |
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| ジャーナル名 | Neurology |
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| 投稿日 | 2019/08/30 |
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| 投稿者 | Ryan, Jennifer M; Peterson, Mark D; Matthews, Anthony; Ryan, Nicola; Smith, Kimberley J; O'Connell, Neil E; Liverani, Silvia; Anokye, Nana; Victor, Christina; Allen, Elizabeth |
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| 組織名 | From the Department of Epidemiology and Public Health Medicine (J.M.R.), Royal;College of Surgeons in Ireland, Dublin; Institute of Environment, Health and;Societies (J.M.R., N.E.O., N.A., C.V.), Brunel University London, UK; Department;of Physical Medicine and Rehabilitation (M.D.P.), University of;Michigan-Medicine, Ann Arbor; Departments of Non-Communicable Disease;Epidemiology (A.M.) and Medical Statistics (E.A.), London School of Hygiene and;Tropical Medicine; Department of Cardiology (N.R.), Aberdeen Royal Infirmary, UK;;Department of Interventional Cardiology (N.R.), Hospital Clinico San Carlos,;Madrid, Spain; Department of Psychological Sciences (K.J.S.), Faculty of Health;and Medical Sciences, University of Surrey, Guildford; and School of Mathematical;Sciences (S.L.), Queen Mary University of London, UK. jenniferryan@rcsi.com.;Sciences (S.L.), Queen Mary University of London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31462583/ |
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