| アブストラクト | BACKGROUND: Two recent studies estimated that users of nonsteroidal antiinflammatory drugs (NSAIDs) have a two-fold increase in risk of hospitalization for congestive heart failure and that this effect is larger among patients with preexisting cardiovascular diseases. METHODS: To evaluate the association between NSAID use and the risk of first-diagnosed episode of heart failure, we conducted a case-control study nested in a population-based cohort of individuals 40-84 years of age and registered in the U.K. General Practice Research Database at 1 January 1996. We excluded patients with a diagnosis of heart failure or cancer before that time and followed source members until a first-time recorded diagnosis of heart failure or cancer, or until 31 December 1996 if no disease occurred. The analysis included 857 confirmed cases and 5000 controls frequency-matched to cases by age (interval of 1 year) and sex. RESULTS: The estimated adjusted relative risk of heart failure associated with prescription of NSAIDs was 1.6 (95% confidence interval = 1.2-2.1). The relative risk was greater during the first month of therapy and was independent of treatment indication. The relative risk was 1.9 (1.3-2.8) among patients with prior history of hypertension, diabetes or renal failure and 1.3 (0.9-1.9) among individuals without these conditions. CONCLUSIONS: Initiation of NSAID therapy may double the risk of developing heart failure in susceptible individuals. Patients with renal failure, diabetes or hypertension when taking NSAIDs might be at a greater risk of developing heart failure than patients without those conditions. |
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| ジャーナル名 | Epidemiology (Cambridge, Mass.) |
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| Pubmed追加日 | 2003/02/28 |
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| 投稿者 | Garcia Rodriguez, Luis Alberto; Hernandez-Diaz, Sonia |
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| 組織名 | Centro Espanol de Investigacion Farmacoepidemiologica, Madrid, Spain.;lagarcia@ceife.es |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/12606892/ |
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