| アブストラクト | BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA. METHODS: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use. RESULTS: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population. CONCLUSION: This study showed that the observed association between OSA and gout disappeared after adjustment. |
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| 投稿者 | van Durme, Caroline; Spaetgens, Bart; Driessen, Johanna; Nielen, Johannes; Sastry, Manuel; Boonen, Annelies; de Vries, Frank |
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| 組織名 | Department of Internal Medicine, Maastricht University Medical Centre+,;Maastricht, The Netherlands.;Department of the Musculoskeletal System, Centre Hospitalier Chretien, Liege,;Belgium.;Department of Clinical Pharmacy and Toxicology, Maastricht University Medical;Centre+, Maastricht, The Netherlands.;CAPHRI, Care and Public Health Research Institute, Maastricht University,;Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for;Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The;Netherlands.;NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht;University Medical Center+, Maastricht, The Netherlands.;Academic Sleep Center CIRO, Horn, The Netherlands.;Centre+, Maastricht, The Netherlands. f.devries@uu.nl.;Netherlands. f.devries@uu.nl.;MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General;Hospital, Southampton, UK. f.devries@uu.nl. |
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