| アブストラクト | PURPOSE: Characterize ocular adverse events (oAEs) caused by immune checkpoint inhibitors (ICIs). METHODS: Retrospective analysis of 41,674 cancer patients in the FDA Adverse Event Reporting System (FAERS) pharmacovigilance database receiving anti-PD-1/PD-L1, anti-CTLA-4, or anti-PD-1+ anti-CTLA-4 combination. Reporting odds ratio (ROR) was used to approximate oAE rate across regimens and indications. RESULTS: The most common indications were lung cancer (27.3%) and melanoma (22.7%); 76.3% received anti-PD-1/PD-L1 monotherapy. 1,268 patients (3.0%) reported oAEs, namely vision disorders (30.8%), uveitis (15.1%), and retinal, lacrimal, and optic nerve disorders (10.7%, 9.0%, 8.4%). Melanoma showed the highest proportion of uveitis (117/9,471 cases; 1.2%). Addition of anti-CTLA-4 to anti-PD-1 increased the ROR of uveitis from 4.77 (95% CI 3.83-5.94) to 17.1 (95% CI 12.9-22.7). Among anti-PD-1/PD-L1 cases, uveitis was differentially reported in melanoma (ROR 14.7, 95% CI 10.7-20.2) compared with lung cancer (ROR 2.67, 95% CI 1.68-4.23). CONCLUSION: ICI-induced oAEs are rare, and uveitis is significantly associated with melanoma and anti-PD-1+ anti-CTLA-4 combination. |
|---|
| ジャーナル名 | Ocular immunology and inflammation |
|---|
| 投稿日 | 2020/8/5 |
|---|
| 投稿者 | Bomze, David; Meirson, Tomer; Hasan Ali, Omar; Goldman, Adam; Flatz, Lukas; Habot-Wilner, Zohar |
|---|
| 組織名 | Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.;Institute for Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.;Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.;Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.;Division of Ophthalmology, Tel-Aviv Medical Center, Sackler Faculty of Medicine,;Tel-Aviv University, Israel. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32749899/ |
|---|
