| アブストラクト | BackgroundIntraocular pressure (IOP)-lowering drugs are essential for glaucoma treatment but can cause ocular and systemic adverse events (AEs). This study utilizes the FDA Adverse Event Reporting System (FAERS) database to investigate the AE signals associated with these drugs.MethodsA retrospective analysis of FAERS data from Q1 2004 to Q4 2023 was conducted. A total of 107,604 AE reports related to IOP-lowering drugs were analyzed using four signal detection methods: ROR, PRR, BCPNN, and MGPS.ResultsSignificant AE signals were identified, including ocular surface damage linked to preservatives, cardiovascular disorders associated with beta-blockers, and ear-related issues with carbonic anhydrase inhibitors and prostaglandin analogs. Carteolol showed a new signal for hepatobiliary disorders.ConclusionsThe study highlights key safety concerns with IOP-lowering drugs, including ocular, cardiovascular, and ear-related AEs. These findings emphasize the need for careful monitoring and further research to confirm these associations and mitigate risks. |
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| ジャーナル名 | The International journal of risk & safety in medicine |
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| Pubmed追加日 | 2026/1/2 |
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| 投稿者 | Liu, Chengzhi; Zhang, Shuaihao; Wang, Xinyu; Dong, Jiaoyue; Shen, Jiaqi; Liu, Mingyue; Cao, Xusheng |
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| 組織名 | Beijing Ophthalmology & Visual Science Key Lab, Beijing Tongren Eye Center,;Beijing Tongren Hospital, Capital Medical University, Beijing, China.;Department of Orthopedic Surgery, Beijing Tongren Hospital, Capital Medical;University, Beijing, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41481114/ |
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